Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3764310..3764899 Replicon chromosome
Accession NZ_CP049017
Organism Xanthomonas theicola strain CFBP 4691

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag G4Q83_RS17540 Protein ID WP_128421422.1
Coordinates 3764720..3764899 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag G4Q83_RS17535 Protein ID WP_128421423.1
Coordinates 3764310..3764720 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G4Q83_RS17530 3762444..3763934 + 1491 WP_128421424.1 FAD-dependent oxidoreductase -
G4Q83_RS17535 3764310..3764720 - 411 WP_128421423.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
G4Q83_RS17540 3764720..3764899 - 180 WP_128421422.1 type II toxin-antitoxin system HicA family toxin Toxin
G4Q83_RS17545 3764987..3765463 - 477 Protein_3456 site-specific DNA-methyltransferase -
G4Q83_RS17550 3765527..3765616 + 90 Protein_3457 integrase -
G4Q83_RS17555 3765732..3765935 - 204 WP_128421421.1 hypothetical protein -
G4Q83_RS17560 3766388..3767097 + 710 Protein_3459 hypothetical protein -
G4Q83_RS17565 3767204..3768360 + 1157 WP_185817245.1 IS3 family transposase -
G4Q83_RS17570 3768365..3769141 - 777 Protein_3461 IS30 family transposase -
G4Q83_RS17575 3769289..3769621 + 333 WP_128420861.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3754689..3782374 27685


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-122)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6648.75 Da        Isoelectric Point: 11.6500

>T150296 WP_128421422.1 NZ_CP049017:c3764899-3764720 [Xanthomonas theicola]
MDSRTLLKQLQAEGFEIVSVRGSHHKLRKGDRTVIVPHPKKDLPAGTVASIFRQAGWRK

Download         Length: 180 bp

>T150296 NZ_CP064671:885934-886347 [Salmonella sp. SJTUF14152]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGTCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCATCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15297.41 Da        Isoelectric Point: 5.2833

>AT150296 WP_128421423.1 NZ_CP049017:c3764720-3764310 [Xanthomonas theicola]
MLYPVYVHKDENSAYGAIVPDMPGVHSAVDSLEDLPAALQEAVELMYEDEERAPPRANIVDKYRRQREFKSGFWMLVDID
LTKINTRAVRLNISLPENLLGKIDAAAATRRMSRSAFLALAAEHELRGEGRKPSTE

Download         Length: 411 bp

>AT150296 NZ_CP064671:885687-885953 [Salmonella sp. SJTUF14152]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References