Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4069801..4070455 Replicon chromosome
Accession NZ_CP049015
Organism Citrobacter freundii ATCC 8090 = MTCC 1658 = NBRC 12681 strain ATCC 8090

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag G4551_RS19510 Protein ID WP_003026936.1
Coordinates 4069801..4070208 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag G4551_RS19515 Protein ID WP_003026938.1
Coordinates 4070189..4070455 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G4551_RS19490 4065744..4067477 - 1734 WP_003838279.1 single-stranded-DNA-specific exonuclease RecJ -
G4551_RS19495 4067483..4068196 - 714 WP_003825520.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
G4551_RS19500 4068225..4069121 - 897 WP_003026928.1 site-specific tyrosine recombinase XerD -
G4551_RS19505 4069235..4069756 + 522 WP_003838276.1 flavodoxin FldB -
G4551_RS19510 4069801..4070208 - 408 WP_003026936.1 protein YgfX Toxin
G4551_RS19515 4070189..4070455 - 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
G4551_RS19520 4070712..4071692 + 981 WP_003838269.1 tRNA-modifying protein YgfZ -
G4551_RS19525 4071786..4072445 - 660 WP_003838267.1 hemolysin III family protein -
G4551_RS19530 4072608..4072919 - 312 WP_003026949.1 N(4)-acetylcytidine aminohydrolase -
G4551_RS19535 4072972..4073700 + 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
G4551_RS19540 4073821..4075254 + 1434 WP_003838263.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T150290 WP_003026936.1 NZ_CP049015:c4070208-4069801 [Citrobacter freundii ATCC 8090 = MTCC 1658 = NBRC 12681]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

>T150290 NZ_CP064666:3628005-3628232 [Salmonella sp. SJTUF14154]
ATGACCACCTATTACTCGCGCATCCCCAGCCTGCACCTTAAGGGCGACTGGCTGGCAGAAGCGGGATTTGATACCGGGGC
GAGCGTGACCGTGAAGATCTCCGAAGGGTGTTTGACTCTGATTGTGGAGACAGACGAAGTGAGGGATCTACGGAGGGAGC
TTTATCAGGTGAAAAAGTCGATGAAGCACATTAAGGCGGGGGTATATGATGTGGTGAACGGGAATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT150290 WP_003026938.1 NZ_CP049015:c4070455-4070189 [Citrobacter freundii ATCC 8090 = MTCC 1658 = NBRC 12681]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT150290 NZ_CP064666:c3628222-3627997 [Salmonella sp. SJTUF14154]
TTCACCACATCATATACCCCCGCCTTAATGTGCTTCATCGACTTTTTCACCTGATAAAGCTCCCTCCGTAGATCCCTCAC
TTCGTCTGTCTCCACAATCAGAGTCAAACACCCTTCGGAGATCTTCACGGTCACGCTCGCCCCGGTATCAAATCCCGCTT
CTGCCAGCCAGTCGCCCTTAAGGTGCAGGCTGGGGATGCGCGAGTAATAGGTGGTCATGTGGGTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References