Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 657930..658506 Replicon chromosome
Accession NZ_CP049015
Organism Citrobacter freundii ATCC 8090 = MTCC 1658 = NBRC 12681 strain ATCC 8090

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag G4551_RS03230 Protein ID WP_003837215.1
Coordinates 657930..658217 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID -
Locus tag G4551_RS03235 Protein ID WP_003837217.1
Coordinates 658204..658506 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G4551_RS03220 654004..656433 - 2430 WP_003837210.1 DEAD/DEAH box helicase family protein -
G4551_RS03225 656529..657695 - 1167 WP_003837213.1 restriction endonuclease -
G4551_RS03230 657930..658217 + 288 WP_003837215.1 BrnT family toxin Toxin
G4551_RS03235 658204..658506 + 303 WP_003837217.1 BrnA antitoxin family protein Antitoxin
G4551_RS03240 658570..659526 - 957 WP_003837219.1 GTPase -
G4551_RS03245 659539..659733 - 195 WP_003830038.1 YbdD/YjiX family protein -
G4551_RS03250 659844..661994 - 2151 WP_003837221.1 pyruvate/proton symporter BtsT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(39-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11130.50 Da        Isoelectric Point: 7.0746

>T150277 WP_003837215.1 NZ_CP049015:657930-658217 [Citrobacter freundii ATCC 8090 = MTCC 1658 = NBRC 12681]
MPMEFEWDANKAQSNLRKHGVRFEDAVLVFDDPQHLSRQDRHENGEYRWQTIGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADSKERSRYEHG

Download         Length: 288 bp

>T150277 NZ_CP064663:2102685-2102788 [Salmonella sp. SJTUF14170]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11513.16 Da        Isoelectric Point: 10.1293

>AT150277 WP_003837217.1 NZ_CP049015:658204-658506 [Citrobacter freundii ATCC 8090 = MTCC 1658 = NBRC 12681]
MNMVKHKRGSISALSAQHEAELKALANKPDDDIDYSDIPVTEDKQWSEATRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT150277 NZ_CP064663:c2102790-2102645 [Salmonella sp. SJTUF14170]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References