Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 246656..247287 Replicon chromosome
Accession NZ_CP049015
Organism Citrobacter freundii ATCC 8090 = MTCC 1658 = NBRC 12681 strain ATCC 8090

Toxin (Protein)


Gene name hicA Uniprot ID A0A0J1MPQ6
Locus tag G4551_RS01145 Protein ID WP_003837806.1
Coordinates 246656..246931 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1MMS0
Locus tag G4551_RS01150 Protein ID WP_003837808.1
Coordinates 246928..247287 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G4551_RS01135 242707..245454 + 2748 WP_003837799.1 ribosome-associated ATPase/putative transporter RbbA -
G4551_RS01140 245454..246578 + 1125 WP_003837801.1 ABC transporter permease -
G4551_RS01145 246656..246931 + 276 WP_003837806.1 type II toxin-antitoxin system HicA family toxin Toxin
G4551_RS01150 246928..247287 + 360 WP_003837808.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
G4551_RS01155 247400..247801 - 402 WP_003023387.1 nickel-responsive transcriptional regulator NikR -
G4551_RS01160 247851..248429 - 579 WP_003837810.1 4'-phosphopantetheinyl transferase AcpT -
G4551_RS01165 248492..249541 - 1050 WP_003837812.1 AI-2E family transporter -
G4551_RS01170 249675..250892 + 1218 WP_003837814.1 MFS transporter -
G4551_RS01175 250896..251453 - 558 WP_003837816.1 DcrB family lipoprotein -
G4551_RS01180 251526..252191 - 666 WP_003837818.1 7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10210.88 Da        Isoelectric Point: 10.7228

>T150274 WP_003837806.1 NZ_CP049015:246656-246931 [Citrobacter freundii ATCC 8090 = MTCC 1658 = NBRC 12681]
MKEKVLSLRKKQKNTLDQLFKAPTPQGIKWSEIESLIKALGGEIKEGRGSRCKFLLNKSIASFHRPHPSPDTDKGAVENV
RDWLTSIGVKP

Download         Length: 276 bp

>T150274 NZ_CP064663:851001-851399 [Salmonella sp. SJTUF14170]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCCGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAGTTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13198.98 Da        Isoelectric Point: 4.5462

>AT150274 WP_003837808.1 NZ_CP049015:246928-247287 [Citrobacter freundii ATCC 8090 = MTCC 1658 = NBRC 12681]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGEISLREYLDDCSAAGIEPYANPEKLKT
FTLRYPESFGERLSFAAAEEQVSVNTWIIETLSKSLKQA

Download         Length: 360 bp

>AT150274 NZ_CP064663:850774-851001 [Salmonella sp. SJTUF14170]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGATGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MPQ6

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MMS0

References