Detailed information of TA system TA150271

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4854128..4854926
• Replicon: chromosome
• Accession: NZ_CP048934
• Organism: Escherichia coli strain 190693

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: Q1RDD2
• Locus tag: G5C00_RS23080
• Protein ID: WP_001094434.1
• Coordinates: 4854552..4854926 (+)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: G5C00_RS23075
• Protein ID: WP_001552747.1
• Coordinates: 4854128..4854505 (+)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G5C00_RS23045	4851006..4851827	+	822	WP_163510514.1	DUF945 domain-containing protein	-
G5C00_RS23050	4851827..4852072	+	246	WP_001164966.1	hypothetical protein	-
G5C00_RS23055	4852166..4852639	+	474	WP_001542276.1	antirestriction protein	-
G5C00_RS23060	4852655..4853131	+	477	WP_001186727.1	RadC family protein	-
G5C00_RS23065	4853194..4853415	+	222	WP_000692315.1	DUF987 domain-containing protein	-
G5C00_RS23070	4853434..4854078	+	645	WP_000086759.1	hypothetical protein	-
G5C00_RS23075	4854128..4854505	+	378	WP_001552747.1	type IV toxin-antitoxin system toxin CbtA	Antitoxin
G5C00_RS23080	4854552..4854926	+	375	WP_001094434.1	TA system toxin CbtA family protein	Toxin
G5C00_RS23085	4854923..4855414	+	492	WP_000976859.1	hypothetical protein	-
G5C00_RS23090	4855426..4855623	+	198	WP_000839257.1	DUF957 domain-containing protein	-
G5C00_RS23095	4855716..4856558	+	843	WP_001280460.1	DUF4942 domain-containing protein	-
G5C00_RS23105	4857029..4857967	+	939	WP_001550942.1	glyoxylate/hydroxypyruvate reductase GhrA	-
G5C00_RS23110	4858022..4858759	+	738	WP_000283664.1	zinc-binding phosphatase	-
G5C00_RS23115	4858783..4859337	+	555	WP_001001909.1	molecular chaperone YcdY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	csgG / csgF / csgE / csgD / csgB / csgA / csgC	4816614..4865495	48881

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13921.82 Da
• Isoelectric Point: 6.8517

>T150271 WP_001094434.1 NZ_CP048934:4854552-4854926 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Nucleotide

• Length: 375 bp

>T150271 NZ_CP064661:c4619092-4618718 [Salmonella sp. SJTUF14178]
ATGGTCAAAGGGTCTGCGCTTTTTGATACCAATATCCTCATCGACCTGTTTAGCGGTCGAATTGAAGCGAAACATGCGCT
GGAAGCGTATCCGCCACAGAATGCGATTAGCCTTATCACATGGATGGAAGTGATGGTGGGTGCTAAGAAATATCATCAGG
AAAACCGCACGCGCATTGCATTAAGTGCGTTCAATATTATTGGCGTAACACAGGAAATCGCGGAGCGAAGCGTCATTGTC
AGGCAGGAGTATGGCATGAAACTCCCGGATGCGATCATTCTGGCCACTGCACAAGTCCATCGTTGTGAGCTTGTGACGCG
TAATACAAAAGACTTTGCCGATATTCCGGGAGTGATCACGCCGTATCACTTCTAG

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 13757.63 Da
• Isoelectric Point: 6.3127

>AT150271 WP_001552747.1 NZ_CP048934:4854128-4854505 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRTGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV

Nucleotide

• Length: 378 bp

>AT150271 NZ_CP064661:c4619334-4619092 [Salmonella sp. SJTUF14178]
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGATGATGTGATTAAACGGCTTGACGATCTCAAGGT
GCAACGCAACCTACCTCGTGCAGAACTCTTGCGGGAGGCCGTTGAGCAGTATCTGGAAAGACAGGATCGGGCTGAGACCA
CAATTTCGAAAGCATTGGGGCTCTGGCAAGGCTGTGAGGAAGATGGCGTTGAATACCAACGTAAACTTCGTGAGGAATGG
TAA

Structures

Toxin

• AlphaFold DB: Q1RDD2