Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4167111..4167729 Replicon chromosome
Accession NZ_CP048934
Organism Escherichia coli strain 190693

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag G5C00_RS19985 Protein ID WP_001291435.1
Coordinates 4167111..4167329 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag G5C00_RS19990 Protein ID WP_000344800.1
Coordinates 4167355..4167729 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5C00_RS19950 4162400..4162972 + 573 WP_000779831.1 YbaY family lipoprotein -
G5C00_RS19955 4163003..4163314 - 312 WP_000409911.1 MGMT family protein -
G5C00_RS19965 4163693..4164046 + 354 WP_001550741.1 DUF1428 family protein -
G5C00_RS19970 4164088..4165638 - 1551 WP_001366446.1 cyclic-guanylate-specific phosphodiesterase PdeB -
G5C00_RS19975 4165802..4166272 - 471 WP_000136192.1 YlaC family protein -
G5C00_RS19980 4166388..4166939 - 552 WP_000102564.1 maltose O-acetyltransferase -
G5C00_RS19985 4167111..4167329 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
G5C00_RS19990 4167355..4167729 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
G5C00_RS19995 4168275..4171424 - 3150 WP_001132480.1 multidrug efflux RND transporter permease subunit -
G5C00_RS20000 4171447..4172640 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T150269 WP_001291435.1 NZ_CP048934:c4167329-4167111 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T150269 NZ_CP064661:3655172-3655399 [Salmonella sp. SJTUF14178]
ATGACCACCTATTACTCGCGCATCCCCAGCCTGCACCTTAAGGGCGACTGGCTGGCAGAAGCGGGATTTGATACCGGGGC
GAGCGTGACCGTGAAGATCTCCGAAGGGTGTTTGACTCTGATTGTGGAGACAGACGAAGTGAGGGATCTACGGAGGGAGC
TTTATCAGGTGAAAAAGTCGATGAAGCACATTAAGGCGGGGGTATATGATGTGGTGAACGGGAATTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT150269 WP_000344800.1 NZ_CP048934:c4167729-4167355 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT150269 NZ_CP064661:c3655389-3655164 [Salmonella sp. SJTUF14178]
TTCACCACATCATATACCCCCGCCTTAATGTGCTTCATCGACTTTTTCACCTGATAAAGCTCCCTCCGTAGATCCCTCAC
TTCGTCTGTCTCCACAATCAGAGTCAAACACCCTTCGGAGATCTTCACGGTCACGCTCGCCCCGGTATCAAATCCCGCTT
CTGCCAGCCAGTCGCCCTTAAGGTGCAGGCTGGGGATGCGCGAGTAATAGGTGGTCATGTGGGTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References