Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3604878..3605386 Replicon chromosome
Accession NZ_CP048934
Organism Escherichia coli strain 190693

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag G5C00_RS17350 Protein ID WP_001534843.1
Coordinates 3604878..3605087 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A0V9L4L3
Locus tag G5C00_RS17355 Protein ID WP_000063161.1
Coordinates 3605084..3605386 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5C00_RS17325 3600063..3600866 - 804 WP_001082319.1 aminoglycoside O-phosphotransferase APH(3'')-Ib -
G5C00_RS17330 3600932..3601111 - 180 Protein_3370 hypothetical protein -
G5C00_RS17335 3601152..3601943 - 792 Protein_3371 restriction endonuclease subunit S -
G5C00_RS17340 3601933..3603552 - 1620 WP_001550561.1 type I restriction-modification system subunit M -
G5C00_RS17345 3603616..3604782 - 1167 WP_001534841.1 restriction endonuclease -
G5C00_RS17350 3604878..3605087 + 210 WP_001534843.1 BrnT family toxin Toxin
G5C00_RS17355 3605084..3605386 + 303 WP_000063161.1 BrnA antitoxin family protein Antitoxin
G5C00_RS17360 3605420..3606376 - 957 WP_001534845.1 GTPase -
G5C00_RS17365 3606387..3606590 - 204 WP_001534846.1 YbdD/YjiX family protein -
G5C00_RS17370 3606708..3608858 - 2151 WP_001366791.1 pyruvate/proton symporter BtsT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7952.17 Da        Isoelectric Point: 4.9493

>T150266 WP_001534843.1 NZ_CP048934:3604878-3605087 [Escherichia coli]
MVDYPKRDAISNINAIIVDTFLYIQLGMATMPMEFEWNANKAKSNRVKHGIRFEDAVLVLDDPQRTEPL

Download         Length: 210 bp

>T150266 NZ_CP064661:2102748-2102851 [Salmonella sp. SJTUF14178]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11600.10 Da        Isoelectric Point: 9.4646

>AT150266 WP_000063161.1 NZ_CP048934:3605084-3605386 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKVLANKFDEDIDYSDIPSSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp

>AT150266 NZ_CP064661:c2102853-2102708 [Salmonella sp. SJTUF14178]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9L4L3

References