Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1843586..1844240 Replicon chromosome
Accession NZ_CP048934
Organism Escherichia coli strain 190693

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag G5C00_RS09000 Protein ID WP_000244781.1
Coordinates 1843586..1843993 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0V9GG32
Locus tag G5C00_RS09005 Protein ID WP_001564007.1
Coordinates 1843974..1844240 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5C00_RS08980 1839543..1841276 - 1734 WP_001564004.1 single-stranded-DNA-specific exonuclease RecJ -
G5C00_RS08985 1841282..1841992 - 711 WP_001564005.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
G5C00_RS08990 1842017..1842913 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
G5C00_RS08995 1843025..1843546 + 522 WP_001055874.1 flavodoxin FldB -
G5C00_RS09000 1843586..1843993 - 408 WP_000244781.1 protein YgfX Toxin
G5C00_RS09005 1843974..1844240 - 267 WP_001564007.1 FAD assembly factor SdhE Antitoxin
G5C00_RS09010 1844483..1845463 + 981 WP_001564008.1 tRNA-modifying protein YgfZ -
G5C00_RS09015 1845540..1846199 - 660 WP_000250274.1 hemolysin III family protein -
G5C00_RS09020 1846363..1846674 - 312 WP_001182966.1 N(4)-acetylcytidine aminohydrolase -
G5C00_RS09025 1846719..1848152 + 1434 WP_163510421.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T150259 WP_000244781.1 NZ_CP048934:c1843993-1843586 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T150259 NZ_CP064658:37437-37940 [Enterobacter hormaechei]
ATGTTTTCAGCACAAGCCGTATACGATTTTTCGGGCTTCGACTGCGGCGAACCATCTCTGAATGATTTCCTGCAAAACCG
CCTGGTACAGCAACACAACGGGCGTATATTACGTGGCTACCTGCTTCTTACCAAAGATCCGGTGCCGAAAGTTAAGGGTT
TTTACACGCTATCCGGGAGCTGTTTTGCAAGACAGACGCTACCATCGAACACCCAGAAGCGGAAAATCCCCTACGCGGAT
GCCCCCAGCGTTACGCTTGGCCGTCTGGCAATAGATATCAGCCTACAGAAACAAGGCTACGGGGAGGTTCTCGTAACGCA
CGCGTTGAAGGTTGTTTATCAGGCTTCTCGCGCAGTAGGCATATACGCTTTGTTTGTGGATGCACTAAACCAAAGCGCAA
TGCAGTTCTATCAGAAGTTTGGATTCATCCCTTTGACGGGGGCAAATGCCAACTCGCTTTTCTACCCCACGAAAAGCATT
GAAGAGCTGTTTGAAACAGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10565.15 Da        Isoelectric Point: 5.1599

>AT150259 WP_001564007.1 NZ_CP048934:c1844240-1843974 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWMMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT150259 NZ_CP064658:37143-37412 [Enterobacter hormaechei]
ATGTCAGCACTGAAAAAACAGCGCATCGATCTCAGATTAACCGACGACGACAAGAGCATGATCGAAGAAGCTGCGGCAAT
GACCAACCAGACGATTACTCAGTTTATGGTTGCCAGTGCCTCTGAACGTGCTGCGGAAGTGATAGAGCAACATCGCCGCT
TGATTCTCAGTGAAGAGTCCTGGAATCTGGTAATGGATGCCATCAGTAACCCGCCTGCACCGAACGATAGGCTGAAACGA
GCTGCCAAACGTCTACAAAGCATGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9GG32

References