Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4960659..4961175 Replicon chromosome
Accession NZ_CP048933
Organism Klebsiella pneumoniae strain KP18-2079

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag G5B45_RS25225 Protein ID WP_002886902.1
Coordinates 4960659..4960943 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag G5B45_RS25230 Protein ID WP_002886901.1
Coordinates 4960933..4961175 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5B45_RS25200 4956143..4956451 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
G5B45_RS25205 4956536..4956709 + 174 WP_002886906.1 hypothetical protein -
G5B45_RS25210 4956712..4957455 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
G5B45_RS25215 4957812..4959950 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
G5B45_RS25220 4960191..4960655 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
G5B45_RS25225 4960659..4960943 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G5B45_RS25230 4960933..4961175 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
G5B45_RS25235 4961253..4963163 - 1911 WP_004152270.1 BglG family transcription antiterminator -
G5B45_RS25240 4963186..4964340 - 1155 WP_002886900.1 lactonase family protein -
G5B45_RS25245 4964406..4965146 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T150244 WP_002886902.1 NZ_CP048933:c4960943-4960659 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T150244 NZ_CP064406:184064-184330 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATATTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGCGGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT150244 WP_002886901.1 NZ_CP048933:c4961175-4960933 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT150244 NZ_CP064406:183801-184064 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTAGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTGGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References