Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4244676..4245295 Replicon chromosome
Accession NZ_CP048933
Organism Klebsiella pneumoniae strain KP18-2079

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag G5B45_RS21700 Protein ID WP_002892050.1
Coordinates 4245077..4245295 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag G5B45_RS21695 Protein ID WP_002892066.1
Coordinates 4244676..4245050 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5B45_RS21685 4239828..4241021 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
G5B45_RS21690 4241044..4244190 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit -
G5B45_RS21695 4244676..4245050 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
G5B45_RS21700 4245077..4245295 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
G5B45_RS21705 4245454..4246020 + 567 WP_002892030.1 maltose O-acetyltransferase -
G5B45_RS21710 4245992..4246132 - 141 WP_004147370.1 hypothetical protein -
G5B45_RS21715 4246153..4246623 + 471 WP_002892026.1 YlaC family protein -
G5B45_RS21720 4246598..4248049 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
G5B45_RS21725 4248150..4248848 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
G5B45_RS21730 4248845..4248985 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
G5B45_RS21735 4248985..4249248 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T150242 WP_002892050.1 NZ_CP048933:4245077-4245295 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T150242 NZ_CP064405:c3784157-3783765 [Mycobacterium tuberculosis variant bovis BCG]
ATGGCGGCCATCTATCTCGACTCGTCCGCGATCGTCAAGCTCGCGGTTCGCGAGCCAGAGTCGGACGCGCTGCGCCGCTA
CCTTCGCACCCGCCACCCGCGAGTGTCGAGTGCCCTTGCGCGCGCGGAGGTCATGCGGGCCCTGCTTGACAAGGGTGAAT
CAGCGCGGAAAGCCGGCCGCCGGGCGCTGGCTCATCTCGATCTGCTGCGCGTCGACAAGCGCGTCCTCGATCTCGCTGGT
GGGCTGCTGCCATTCGAGCTGCGCACGCTCGATGCCATCCACTTGGCGACGGCGCAGCGGCTCGGCGTCGATCTGGGCCG
GTTGTGCACCTACGACGACCGGATGCGCGACGCCGCCAAGACGCTCGGCATGGCCGTGATCGCCCCGTCGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT150242 WP_002892066.1 NZ_CP048933:4244676-4245050 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT150242 NZ_CP064405:c3784432-3784157 [Mycobacterium tuberculosis variant bovis BCG]
ATGACCTCGGTGGGGGTGCGTGCGCTGCGGCAGCGGGCCAGCGAGCTGCTGCGCCGAGTCGAGGCCGGCGAGACGATCGA
GATCACCGACCGCGGCCGGCCCGTCGCCCTGCTCTCGCCGCTGCCGCAGGGCGGTCCATACGAGCAGCTGCTGGCAAGCG
GCGAGATCGAGCGTGCCACGCTCGACGTCGTTGATCTGCCCGAACCGCTCGACCTCGACGCGGGCGTCGAGCTGCCGTCG
GTGACGCTTGCGCGCCTGCGTGAGCACGAGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References