Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 876814..877468 Replicon chromosome
Accession NZ_CP048933
Organism Klebsiella pneumoniae strain KP18-2079

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag G5B45_RS04495 Protein ID WP_004144731.1
Coordinates 877061..877468 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag G5B45_RS04490 Protein ID WP_002916312.1
Coordinates 876814..877080 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5B45_RS04465 871970..873403 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
G5B45_RS04470 873522..874250 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
G5B45_RS04475 874300..874611 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
G5B45_RS04480 874775..875434 + 660 WP_002916317.1 hemolysin III family protein -
G5B45_RS04485 875585..876568 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
G5B45_RS04490 876814..877080 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
G5B45_RS04495 877061..877468 + 408 WP_004144731.1 protein YgfX Toxin
G5B45_RS04500 877475..877996 - 522 WP_002916308.1 flavodoxin FldB -
G5B45_RS04505 878097..878993 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
G5B45_RS04510 879016..879729 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
G5B45_RS04515 879735..881468 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T150232 WP_004144731.1 NZ_CP048933:877061-877468 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T150232 NZ_CP064405:c3017108-3016692 [Mycobacterium tuberculosis variant bovis BCG]
ATGACCACGCGCTATTTGCTCGACAAATCAGCGGCTTACCGCGCGCACTTGCCCGCGGTCCGACATCGCTTGGAACCGTT
GATGGAACGCGGTCTACTGGCCCGGTGCGGCATTACCGATCTCGAGTTCGGAGTCTCGGCGCGTTCCCGCGAGGACCATC
GAACACTGGGCACCTACCGGCGTGACGCGCTCGAATACGTCAACACCCCCGACACCGTGTGGGTTCGTGCATGGGAGATC
CAAGAAGCATTGACCGACAAGGGATTTCACCGCTCGGTCAAGATCCCGGACTTGATCATTGCGGCGGTCGCCGAGCATCA
CGGCATACCCGTCATGCACTACGACCAAGACTTCGAACGCATCGCCGCCATCACACGGCAACCCGTGGAATGGGTGGTGG
CCCCAGGGACAGCGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT150232 WP_002916312.1 NZ_CP048933:876814-877080 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT150232 NZ_CP064405:c3017371-3017105 [Mycobacterium tuberculosis variant bovis BCG]
ATGCATCGCGGATATGCATTAGTAGTATGCTCTCCGGGTGTGACGCGCACCATGATCGACATCGATGACGACCTGCTCGC
TCGGGCCGCCAAGGAACTGGGTACCACGACAAAGAAAGACACCGTGCATGCCGCGCTGCGGGCCGCGTTGCGAGCCAGTG
CCGCGCGCTCGCTCATGAACCGGATGGCCGAGAACGCCACCGGAACCCAGGACGAAGCTCTGGTCAACGCAATGTGGCGA
GACGGCCACCCAGAGAACACGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References