Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1581393..1582078 | Replicon | chromosome |
| Accession | NZ_CP048929 | ||
| Organism | Neisseria gonorrhoeae strain CT213 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | Q5F6D1 |
| Locus tag | G5S46_RS08135 | Protein ID | WP_003689143.1 |
| Coordinates | 1581896..1582078 (-) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | Q5F6D2 |
| Locus tag | G5S46_RS08130 | Protein ID | WP_003691454.1 |
| Coordinates | 1581393..1581794 (-) | Length | 134 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G5S46_RS08075 (G5S46_07975) | 1576453..1576668 | - | 216 | WP_003691538.1 | hypothetical protein | - |
| G5S46_RS08080 (G5S46_07980) | 1576720..1577211 | - | 492 | WP_047926688.1 | siphovirus Gp157 family protein | - |
| G5S46_RS08085 (G5S46_07985) | 1577208..1577390 | - | 183 | WP_003691535.1 | hypothetical protein | - |
| G5S46_RS08090 (G5S46_07990) | 1577530..1578216 | - | 687 | WP_042758540.1 | hypothetical protein | - |
| G5S46_RS08095 | 1578285..1578446 | - | 162 | WP_004464809.1 | hypothetical protein | - |
| G5S46_RS08100 (G5S46_07995) | 1578443..1578718 | - | 276 | WP_010359972.1 | hypothetical protein | - |
| G5S46_RS08105 (G5S46_08000) | 1578873..1579205 | - | 333 | WP_003687946.1 | hypothetical protein | - |
| G5S46_RS08110 (G5S46_08005) | 1579347..1579616 | - | 270 | WP_219501095.1 | hypothetical protein | - |
| G5S46_RS08115 (G5S46_08010) | 1579613..1580089 | - | 477 | WP_002255718.1 | hypothetical protein | - |
| G5S46_RS08120 (G5S46_08015) | 1580122..1580322 | - | 201 | WP_003704298.1 | hypothetical protein | - |
| G5S46_RS08125 (G5S46_08020) | 1580533..1581294 | + | 762 | WP_012503753.1 | hypothetical protein | - |
| G5S46_RS08130 (G5S46_08025) | 1581393..1581794 | - | 402 | WP_003691454.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| G5S46_RS08135 (G5S46_08030) | 1581896..1582078 | - | 183 | WP_003689143.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| G5S46_RS08140 (G5S46_08035) | 1582248..1583066 | - | 819 | WP_012503752.1 | DUF3037 domain-containing protein | - |
| G5S46_RS08145 (G5S46_08040) | 1583063..1583761 | - | 699 | WP_003689139.1 | hypothetical protein | - |
| G5S46_RS08150 (G5S46_08045) | 1584000..1584710 | - | 711 | WP_050161643.1 | helix-turn-helix transcriptional regulator | - |
| G5S46_RS08155 (G5S46_08050) | 1584826..1585014 | + | 189 | WP_003689136.1 | helix-turn-helix domain-containing protein | - |
| G5S46_RS08160 | 1585094..1585249 | + | 156 | WP_123788359.1 | hypothetical protein | - |
| G5S46_RS08165 (G5S46_08055) | 1585226..1585414 | - | 189 | WP_219501097.1 | hypothetical protein | - |
| G5S46_RS08170 (G5S46_08060) | 1585587..1585814 | + | 228 | WP_003698261.1 | helix-turn-helix domain-containing protein | - |
| G5S46_RS12140 | 1586493..1586996 | + | 504 | WP_010360005.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 1566225..1600479 | 34254 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6687.77 Da Isoelectric Point: 10.7235
>T150227 WP_003689143.1 NZ_CP048929:c1582078-1581896 [Neisseria gonorrhoeae]
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
Download Length: 183 bp
>T150227 NZ_CP064405:c2811555-2811136 [Mycobacterium tuberculosis variant bovis BCG]
GTGACGGCACTGCTCGATGTCAATGTGCTGATCGCGCTGGGCTGGCCGAATCACGTTCACCATGCGGCCGCGCAGCGATG
GTTCACGCAGTTCTCCTCGAATGGGTGGGCCACCACGCCGATCACCGAGGCAGGGTATGTCCGAATTTCAAGCAATCGCA
GTGTGATGCAGGTGTCGACCACGCCGGCTATCGCGATCGCTCAGTTGGCGGCGATGACTTCTCTTGCCGGGCACACGTTT
TGGCCTGACGATGTGCCACTGATCGTTGGGAGCGCCGGCGATCGCGATGCGGTGTCCAACCACCGTCGGGTCACCGACTG
CCATCTCATCGCCTTGGCCGCGCGCTACGGGGGCCGGTTGGTCACATTCGATGCCGCACTGGCCGATTCAGCATCCGCAG
GCCTCGTCGAGGTGTTGTAG
GTGACGGCACTGCTCGATGTCAATGTGCTGATCGCGCTGGGCTGGCCGAATCACGTTCACCATGCGGCCGCGCAGCGATG
GTTCACGCAGTTCTCCTCGAATGGGTGGGCCACCACGCCGATCACCGAGGCAGGGTATGTCCGAATTTCAAGCAATCGCA
GTGTGATGCAGGTGTCGACCACGCCGGCTATCGCGATCGCTCAGTTGGCGGCGATGACTTCTCTTGCCGGGCACACGTTT
TGGCCTGACGATGTGCCACTGATCGTTGGGAGCGCCGGCGATCGCGATGCGGTGTCCAACCACCGTCGGGTCACCGACTG
CCATCTCATCGCCTTGGCCGCGCGCTACGGGGGCCGGTTGGTCACATTCGATGCCGCACTGGCCGATTCAGCATCCGCAG
GCCTCGTCGAGGTGTTGTAG
Antitoxin
Download Length: 134 a.a. Molecular weight: 14634.43 Da Isoelectric Point: 4.5457
>AT150227 WP_003691454.1 NZ_CP048929:c1581794-1581393 [Neisseria gonorrhoeae]
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
Download Length: 402 bp
>AT150227 NZ_CP064405:c2811776-2811552 [Mycobacterium tuberculosis variant bovis BCG]
ATGCGCACCACGTTGCAGATTGATGATGATGTTCTAGAAGATGCTCGTAGCATCGCGCGGTCGGAGGGCAAGTCAGTCGG
CGCGGTAATTTCTGAGTTGGCGCGTAGGTCGCTCCGTCCGGTTGGGATTGTCGAGGTTGACGGATTTCCGGTTTTTGATG
TTCCGCCGGATGCGCCGACGGTGACTTCCGAGGATGTCGTCCGCGCGCTCGAGGACGACGTGTGA
ATGCGCACCACGTTGCAGATTGATGATGATGTTCTAGAAGATGCTCGTAGCATCGCGCGGTCGGAGGGCAAGTCAGTCGG
CGCGGTAATTTCTGAGTTGGCGCGTAGGTCGCTCCGTCCGGTTGGGATTGTCGAGGTTGACGGATTTCCGGTTTTTGATG
TTCCGCCGGATGCGCCGACGGTGACTTCCGAGGATGTCGTCCGCGCGCTCGAGGACGACGTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|