Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 947153..947808 Replicon chromosome
Accession NZ_CP048908
Organism Neisseria gonorrhoeae strain SRRSH203

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag G4V51_RS04845 Protein ID WP_003691083.1
Coordinates 947153..947572 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag G4V51_RS04850 Protein ID WP_003688410.1
Coordinates 947572..947808 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G4V51_RS04825 942387..943928 - 1542 WP_003688418.1 multidrug efflux MFS transporter -
G4V51_RS04830 944076..944855 + 780 WP_003688416.1 (Fe-S)-binding protein -
G4V51_RS04835 944852..945553 + 702 WP_003688414.1 lactate utilization protein C -
G4V51_RS04840 945550..947004 + 1455 WP_003688412.1 iron-sulfur cluster-binding protein -
G4V51_RS04845 947153..947572 - 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
G4V51_RS04850 947572..947808 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
G4V51_RS04855 948014..948211 - 198 WP_033910354.1 IS3 family transposase -
G4V51_RS04860 948256..948834 - 579 WP_003688041.1 IS3 family transposase -
G4V51_RS04865 948839..949267 - 429 WP_010360042.1 helix-turn-helix domain-containing protein -
G4V51_RS04870 949479..949865 + 387 Protein_955 IS110 family transposase -
G4V51_RS04875 950248..951138 - 891 WP_003693285.1 succinate--CoA ligase subunit alpha -
G4V51_RS04880 951149..952315 - 1167 WP_003701280.1 ADP-forming succinate--CoA ligase subunit beta -
G4V51_RS04885 952387..952674 - 288 WP_025455945.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T150164 WP_003691083.1 NZ_CP048908:c947572-947153 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

>T150164 NZ_CP064399:c4980372-4980025 [Pseudomonas aeruginosa]
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGTTCCATTCCA
AGGTGAACAGGCTGCATTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCAGCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGTGGCAGTGATCTTGGTTTTGCGACAGAAGCAGAGCGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT150164 WP_003688410.1 NZ_CP048908:c947808-947572 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp

>AT150164 NZ_CP064399:c4980633-4980382 [Pseudomonas aeruginosa]
ATGCGAGTCGAGACAATTAGTTATTTGAAACGTCATGCGGCTGACTTGGATTTATCCGAGCCAATGGTCGTCACGCAGAA
CGGTGTTCCTGCCTATGTGGTTGAGTCATATGCTGAGCGGAAGCAGCGCGATGAAGCAATTGCGCTGGTGAAGTTGCTTG
CGATTGGCTCCCGCCAGTACGCAGAAGGCAAGCATCGCTCTGTTGATGATTTGAAAGCTCGCCTTTCCAGGAGGTTCGCT
CAGCCAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References