150163

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 241..704 Replicon plasmid unnamed2
Accession NZ_CP048907
Organism Neisseria gonorrhoeae strain SRRSH205

Toxin (Protein)


Gene name VapD Uniprot ID Q51003
Locus tag G4V52_RS11870 Protein ID WP_003690225.1
Coordinates 241..519 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID Q51002
Locus tag G4V52_RS11875 Protein ID WP_003690223.1
Coordinates 519..704 (-) Length 62 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G4V52_RS11865 9..263 + 255 WP_003690227.1 Cryptic plasmid protein A -
G4V52_RS11870 241..519 - 279 WP_003690225.1 endoribonuclease VapD Toxin
G4V52_RS11875 519..704 - 186 WP_003690223.1 DUF5397 family protein Antitoxin
G4V52_RS11880 707..952 - 246 WP_003690221.1 hypothetical protein -
G4V52_RS11885 949..1191 - 243 WP_003690220.1 HTH domain-containing protein -
G4V52_RS11890 1195..1977 - 783 WP_010359605.1 replication initiation protein -
G4V52_RS11895 2147..2371 - 225 WP_025455920.1 hypothetical protein -
G4V52_RS11900 2639..2830 + 192 WP_003690218.1 plasmid mobilization relaxosome protein MobC -
G4V52_RS11905 2815..3444 + 630 WP_003696452.1 relaxase/mobilization nuclease domain-containing protein -
G4V52_RS11910 3528..4169 + 642 WP_003690229.1 Cryptic plasmid protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..4207 4207


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(2-60)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10473.89 Da        Isoelectric Point: 6.9726

>T150163 WP_003690225.1 NZ_CP048907:c519-241 [Neisseria gonorrhoeae]
MYAISFDLVVADTAQNHPKGISQAYADIGYTLRKFGFTRIQGSLYTCQNEDMANLFSAINELKALPWFPSSVRDIRAFRI
EQWSDFTSLVKS

Download         Length: 279 bp

>T150163 NZ_CP064399:c4838084-4837719 [Pseudomonas aeruginosa]
GTGGCGTGGGATATCGAGTACACCGACGAGTTCGGTGATTGGTGGGGTTCTCTGTCCGAGGATGAGCAGGAGTCGCTAGC
TGTGACGGTTCGCTTGCTTGAGGAGCGGGGGCCATCCTTGGGGCACCCCCACAGCAGCGGCATCAATGGCTCCCGCCATG
GCCATATGAGAGAGCTACGGACTCAACACGGCGGGCGACCTTTCCGAACGCTTTACGCGTTTGATCCCAGACGCTCCGCG
ATACTGCTGATCGGTGGCGACAAGACTGGCGATGATCGTTGGTACGAATTGAACGTGCCCATTGCTGACCGCCTCTATGA
CGAACACTTGCACCAGCTCCGTGAGGAGGGACTGATCGATGGCTAA

Antitoxin


Download         Length: 62 a.a.        Molecular weight: 6717.54 Da        Isoelectric Point: 4.2641

>AT150163 WP_003690223.1 NZ_CP048907:c704-519 [Neisseria gonorrhoeae]
MQTTIPTGSIRTFGDYGVMYIVGTPAEQLPDGDWLVNIELPESGEHTQYKLSHIVQDPKAA

Download         Length: 186 bp

>AT150163 NZ_CP064399:c4837726-4837403 [Pseudomonas aeruginosa]
ATGGCTAAGAAATTCTCCGACCTTCGGGCGCAAATGTCGCCTGAGGGACAGGCCCGCGTCGAGGCCAAGGCCCAGGAACT
GTTGGCTGAAATGCCCCTGAATGAGTTGCGCCAGGCTAGAGGCTTGTCGCAGAAGATGCTGTCTGAAGTGCTGCACGTGC
AGCAGCCGGCAATTGCCAAAATGGAGCGGCGTACGGATATGTACATCTCCACCTTGCGCAGCCACATCGAAGCCATGGGC
GGCCAGCTGGAAGTGATCGCACGCTTCCCGGATGGCGCGGTGAAAATCAGCAACTTCGCTGATATCGAAGAGGCGGGCGC
CTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H5FJI5

Antitoxin

Source ID Structure
AlphaFold DB Q51002

References