Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 946258..946913 Replicon chromosome
Accession NZ_CP048902
Organism Neisseria gonorrhoeae strain SRRSH207

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag G4V53_RS04835 Protein ID WP_003691083.1
Coordinates 946258..946677 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag G4V53_RS04840 Protein ID WP_003688410.1
Coordinates 946677..946913 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G4V53_RS04815 941492..943033 - 1542 WP_003701286.1 multidrug efflux MFS transporter -
G4V53_RS04820 943181..943960 + 780 WP_003688416.1 (Fe-S)-binding protein -
G4V53_RS04825 943957..944658 + 702 WP_003688414.1 lactate utilization protein C -
G4V53_RS04830 944655..946109 + 1455 WP_003688412.1 iron-sulfur cluster-binding protein -
G4V53_RS04835 946258..946677 - 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
G4V53_RS04840 946677..946913 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
G4V53_RS04845 947119..947364 - 246 WP_003706295.1 IS3 family transposase -
G4V53_RS04850 947361..947939 - 579 WP_003688041.1 IS3 family transposase -
G4V53_RS04855 947944..948372 - 429 WP_010360042.1 helix-turn-helix domain-containing protein -
G4V53_RS04860 948584..948970 + 387 Protein_960 IS110 family transposase -
G4V53_RS04865 949353..950243 - 891 WP_003693285.1 succinate--CoA ligase subunit alpha -
G4V53_RS04870 950254..951420 - 1167 WP_003701280.1 ADP-forming succinate--CoA ligase subunit beta -
G4V53_RS04875 951492..951779 - 288 WP_025455945.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T150158 WP_003691083.1 NZ_CP048902:c946677-946258 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

>T150158 NZ_CP064399:c144459-144178 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT150158 WP_003688410.1 NZ_CP048902:c946913-946677 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp

>AT150158 NZ_CP064399:c144683-144456 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References