Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta(toxin)
Location 9725..11376 Replicon plasmid unnamed1
Accession NZ_CP048900
Organism Neisseria gonorrhoeae strain SRRSH214

Toxin (Protein)


Gene name ng_zeta1 Uniprot ID -
Locus tag G4V50_RS11675 Protein ID WP_033911112.1
Coordinates 9725..10930 (+) Length 402 a.a.

Antitoxin (Protein)


Gene name ng_epsilon1 Uniprot ID D5K9G8
Locus tag G4V50_RS11680 Protein ID WP_003701903.1
Coordinates 10945..11376 (+) Length 144 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G4V50_RS11640 5313..5681 + 369 WP_003701920.1 hypothetical protein -
G4V50_RS11645 5665..6036 + 372 WP_003701919.1 hypothetical protein -
G4V50_RS11650 6040..6936 + 897 WP_003701917.1 hypothetical protein -
G4V50_RS11655 7088..7576 - 489 WP_014580055.1 hypothetical protein -
G4V50_RS11660 8046..8294 + 249 WP_014580056.1 hypothetical protein -
G4V50_RS11665 8291..9499 + 1209 WP_014580057.1 zeta toxin family protein -
G4V50_RS11670 9533..9718 + 186 WP_014580058.1 hypothetical protein -
G4V50_RS11675 9725..10930 + 1206 WP_033911112.1 zeta toxin family protein Toxin
G4V50_RS11680 10945..11376 + 432 WP_003701903.1 hypothetical protein Antitoxin
G4V50_RS11685 11428..11982 + 555 WP_003701901.1 recombinase family protein -
G4V50_RS11690 12092..12382 - 291 WP_003701899.1 virulence factor -
G4V50_RS11695 12485..13084 - 600 WP_003701898.1 TrbN protein -
G4V50_RS11700 13084..13662 - 579 WP_033911116.1 TrbM protein -
G4V50_RS11705 13649..15276 - 1628 Protein_19 P-type conjugative transfer protein TrbL -
G4V50_RS11710 15490..16266 - 777 WP_003701891.1 P-type conjugative transfer protein TrbJ -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..39059 39059


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(284-343)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 402 a.a.        Molecular weight: 44747.59 Da        Isoelectric Point: 7.2930

>T150156 WP_033911112.1 NZ_CP048900:9725-10930 [Neisseria gonorrhoeae]
MVKLSSDINLRDFGNNEYLSSVQDEAIRFATEQTDEILSLYSQHADTEGGRYVCADTFKELFPAFENKEDRATVNNAIHN
SAAVLSSTQFDEVLKRDEPQKKEVIFVTGIPGSGKTSTVKNMMMQDTTKLLFEGQLARPQSAFRKIEQCLERNLEVTIVA
VSMRAERASDNTYKRFNEYGREASIGIMADIQANLPDGLKQIRDKFGDAVKIVGINQDRNSEFIDKFDDVIKMLSLGSQE
QILGRLAEKIQSDFDSGKISRECFNQAKGSMDLESVFAKKEYSQQRVVTNSKGVTLETKSANELWSKVEQIPVTGMKAGI
YLLGQAKKAETGQTYSGEIIYKDAAAVFQKTKNGLVRHNATHNEERLAKLVEIGQNVSIGSNKGKLIVKSLEYSAKKSIS
R

Download         Length: 1206 bp

>T150156 NZ_CP064397:c5653901-5653602 [Pseudomonas aeruginosa]
ATGGTCGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCAAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATCCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAGTGGAGGCCGCAATGA

Antitoxin


Download         Length: 144 a.a.        Molecular weight: 15927.05 Da        Isoelectric Point: 4.4211

>AT150156 WP_003701903.1 NZ_CP048900:10945-11376 [Neisseria gonorrhoeae]
MKEKMRLITEISLIIRELSYSRRGYRPESYAAALDNLTIIGDLADILHNIEAATGNPFVQRMVDEKLRKFVTDFPAYKVR
LSPFLNGCPHDLSLGAESLGKGESIADALAVPPEEVDIADIEFDRVLIEDDRWTGAYDGGNAQ

Download         Length: 432 bp

>AT150156 NZ_CP064397:c5653605-5653315 [Pseudomonas aeruginosa]
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGACAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
TTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCCCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCTACATTGAAAACCATGCTGGCA
GTAATGCGAGCTCTGGGAGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB D5K9G8

References