Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | omega-epsilon-zeta/zeta(toxin) |
Location | 9725..11376 | Replicon | plasmid unnamed1 |
Accession | NZ_CP048900 | ||
Organism | Neisseria gonorrhoeae strain SRRSH214 |
Toxin (Protein)
Gene name | ng_zeta1 | Uniprot ID | - |
Locus tag | G4V50_RS11675 | Protein ID | WP_033911112.1 |
Coordinates | 9725..10930 (+) | Length | 402 a.a. |
Antitoxin (Protein)
Gene name | ng_epsilon1 | Uniprot ID | D5K9G8 |
Locus tag | G4V50_RS11680 | Protein ID | WP_003701903.1 |
Coordinates | 10945..11376 (+) | Length | 144 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
G4V50_RS11640 | 5313..5681 | + | 369 | WP_003701920.1 | hypothetical protein | - |
G4V50_RS11645 | 5665..6036 | + | 372 | WP_003701919.1 | hypothetical protein | - |
G4V50_RS11650 | 6040..6936 | + | 897 | WP_003701917.1 | hypothetical protein | - |
G4V50_RS11655 | 7088..7576 | - | 489 | WP_014580055.1 | hypothetical protein | - |
G4V50_RS11660 | 8046..8294 | + | 249 | WP_014580056.1 | hypothetical protein | - |
G4V50_RS11665 | 8291..9499 | + | 1209 | WP_014580057.1 | zeta toxin family protein | - |
G4V50_RS11670 | 9533..9718 | + | 186 | WP_014580058.1 | hypothetical protein | - |
G4V50_RS11675 | 9725..10930 | + | 1206 | WP_033911112.1 | zeta toxin family protein | Toxin |
G4V50_RS11680 | 10945..11376 | + | 432 | WP_003701903.1 | hypothetical protein | Antitoxin |
G4V50_RS11685 | 11428..11982 | + | 555 | WP_003701901.1 | recombinase family protein | - |
G4V50_RS11690 | 12092..12382 | - | 291 | WP_003701899.1 | virulence factor | - |
G4V50_RS11695 | 12485..13084 | - | 600 | WP_003701898.1 | TrbN protein | - |
G4V50_RS11700 | 13084..13662 | - | 579 | WP_033911116.1 | TrbM protein | - |
G4V50_RS11705 | 13649..15276 | - | 1628 | Protein_19 | P-type conjugative transfer protein TrbL | - |
G4V50_RS11710 | 15490..16266 | - | 777 | WP_003701891.1 | P-type conjugative transfer protein TrbJ | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | - | 1..39059 | 39059 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 402 a.a. Molecular weight: 44747.59 Da Isoelectric Point: 7.2930
>T150156 WP_033911112.1 NZ_CP048900:9725-10930 [Neisseria gonorrhoeae]
MVKLSSDINLRDFGNNEYLSSVQDEAIRFATEQTDEILSLYSQHADTEGGRYVCADTFKELFPAFENKEDRATVNNAIHN
SAAVLSSTQFDEVLKRDEPQKKEVIFVTGIPGSGKTSTVKNMMMQDTTKLLFEGQLARPQSAFRKIEQCLERNLEVTIVA
VSMRAERASDNTYKRFNEYGREASIGIMADIQANLPDGLKQIRDKFGDAVKIVGINQDRNSEFIDKFDDVIKMLSLGSQE
QILGRLAEKIQSDFDSGKISRECFNQAKGSMDLESVFAKKEYSQQRVVTNSKGVTLETKSANELWSKVEQIPVTGMKAGI
YLLGQAKKAETGQTYSGEIIYKDAAAVFQKTKNGLVRHNATHNEERLAKLVEIGQNVSIGSNKGKLIVKSLEYSAKKSIS
R
MVKLSSDINLRDFGNNEYLSSVQDEAIRFATEQTDEILSLYSQHADTEGGRYVCADTFKELFPAFENKEDRATVNNAIHN
SAAVLSSTQFDEVLKRDEPQKKEVIFVTGIPGSGKTSTVKNMMMQDTTKLLFEGQLARPQSAFRKIEQCLERNLEVTIVA
VSMRAERASDNTYKRFNEYGREASIGIMADIQANLPDGLKQIRDKFGDAVKIVGINQDRNSEFIDKFDDVIKMLSLGSQE
QILGRLAEKIQSDFDSGKISRECFNQAKGSMDLESVFAKKEYSQQRVVTNSKGVTLETKSANELWSKVEQIPVTGMKAGI
YLLGQAKKAETGQTYSGEIIYKDAAAVFQKTKNGLVRHNATHNEERLAKLVEIGQNVSIGSNKGKLIVKSLEYSAKKSIS
R
Download Length: 1206 bp
>T150156 NZ_CP064397:c5653901-5653602 [Pseudomonas aeruginosa]
ATGGTCGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCAAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATCCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAGTGGAGGCCGCAATGA
ATGGTCGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCAAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATCCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAGTGGAGGCCGCAATGA
Antitoxin
Download Length: 144 a.a. Molecular weight: 15927.05 Da Isoelectric Point: 4.4211
>AT150156 WP_003701903.1 NZ_CP048900:10945-11376 [Neisseria gonorrhoeae]
MKEKMRLITEISLIIRELSYSRRGYRPESYAAALDNLTIIGDLADILHNIEAATGNPFVQRMVDEKLRKFVTDFPAYKVR
LSPFLNGCPHDLSLGAESLGKGESIADALAVPPEEVDIADIEFDRVLIEDDRWTGAYDGGNAQ
MKEKMRLITEISLIIRELSYSRRGYRPESYAAALDNLTIIGDLADILHNIEAATGNPFVQRMVDEKLRKFVTDFPAYKVR
LSPFLNGCPHDLSLGAESLGKGESIADALAVPPEEVDIADIEFDRVLIEDDRWTGAYDGGNAQ
Download Length: 432 bp
>AT150156 NZ_CP064397:c5653605-5653315 [Pseudomonas aeruginosa]
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGACAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
TTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCCCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCTACATTGAAAACCATGCTGGCA
GTAATGCGAGCTCTGGGAGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGACAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
TTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCCCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCTACATTGAAAACCATGCTGGCA
GTAATGCGAGCTCTGGGAGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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