Detailed information of TA system TA150149

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yxiD-yxxD/-
• Location: 3356091..3356872
• Replicon: chromosome
• Accession: NZ_CP048883
• Organism: Priestia megaterium strain Mes11

Toxin (Protein)

• Gene name: yxiD
• Uniprot ID: -
• Locus tag: BMG_RS17925
• Protein ID: WP_075420344.1
• Coordinates: 3356522..3356872 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: yxxD
• Uniprot ID: D5DPQ5
• Locus tag: BMG_RS17920
• Protein ID: WP_013056651.1
• Coordinates: 3356091..3356519 (-)
• Length: 143 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BMG_RS17905	3351169..3352086	-	918	WP_049787036.1	hypothetical protein	-
BMG_RS17910	3352079..3353944	-	1866	WP_013056653.1	AAA family ATPase	-
BMG_RS17915	3354422..3355573	-	1152	WP_013056652.1	suppressor of fused domain protein	-
BMG_RS17920	3356091..3356519	-	429	WP_013056651.1	SMI1/KNR4 family protein	Antitoxin
BMG_RS17925	3356522..3356872	-	351	WP_075420344.1	HNH endonuclease	Toxin
BMG_RS17930	3357414..3359570	-	2157	WP_013056649.1	type IA DNA topoisomerase	-
BMG_RS17935	3359687..3360535	-	849	WP_162485295.1	GIY-YIG nuclease family protein	-
BMG_RS17940	3361107..3361370	+	264	WP_013056647.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 13874.50 Da
• Isoelectric Point: 9.3682

>T150149 WP_075420344.1 NZ_CP048883:c3356872-3356522 [Priestia megaterium]
VEFLKESLRNNKFEKLTPKETAKHRGRFTTSLKNKLIEEWEEKTNQKWPRYTEEVYDQSGEIARHIGQPYDAHHLIENNF
SGPHEWWNIHPAKYPDEHQQGIHGKGAPSRMLFPRR

Nucleotide

• Length: 351 bp

>T150149 NZ_CP064397:c176383-176102 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACACCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 143 a.a.
• Molecular weight: 16623.64 Da
• Isoelectric Point: 3.9139

>AT150149 WP_013056651.1 NZ_CP048883:c3356519-3356091 [Priestia megaterium]
MADFKFINNGENKIYNLSEEEILKAEDRMGIRFPDDLRQLYLEVGYGFIKEPSNNAINRIMGPGTVANVKLREGVFEFDP
DLDELDEEDKLIFFEVNEGIYISLDLKLPNNPVFYFDTQIADSLEDFLKKFINDNEYYIDLE

Nucleotide

• Length: 429 bp

>AT150149 NZ_CP064397:c176607-176380 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Structures

Antitoxin

• AlphaFold DB: A0A7W3N954