Detailed information of TA system TA150142

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelB-YoeB
• Location: 21344..21849
• Replicon: plasmid pB
• Accession: NZ_CP048880
• Organism: Spartinivicinus ruber strain S2-4-1H

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: G4Y78_RS29535
• Protein ID: WP_163836097.1
• Coordinates: 21344..21598 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: G4Y78_RS29540
• Protein ID: WP_163836100.1
• Coordinates: 21595..21849 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G4Y78_RS29500	17172..18410	-	1239	WP_163836813.1	ATP-binding protein	-
G4Y78_RS29505	19021..19230	+	210	WP_163836913.1	cold-shock protein	-
G4Y78_RS29510	19278..19577	-	300	WP_163836814.1	helix-turn-helix domain-containing protein	-
G4Y78_RS29515	19691..19924	+	234	WP_163836104.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
G4Y78_RS29520	19924..20337	+	414	WP_163836103.1	type II toxin-antitoxin system VapC family toxin	-
G4Y78_RS29525	20367..20549	+	183	WP_163836815.1	hypothetical protein	-
G4Y78_RS29530	20577..21233	-	657	WP_163836101.1	type II toxin-antitoxin system HicB family antitoxin	-
G4Y78_RS29535	21344..21598	+	255	WP_163836097.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Toxin
G4Y78_RS29540	21595..21849	+	255	WP_163836100.1	Txe/YoeB family addiction module toxin	Antitoxin
G4Y78_RS29545	22288..22554	+	267	WP_163836099.1	hypothetical protein	-
G4Y78_RS29550	22544..22924	+	381	WP_163836098.1	type II toxin-antitoxin system VapC family toxin	-
G4Y78_RS29555	23140..23646	-	507	WP_163836816.1	N-acetyltransferase	-
G4Y78_RS29560	23917..24150	+	234	WP_163836817.1	hypothetical protein	-
G4Y78_RS29565	24422..25966	+	1545	WP_163836818.1	RHS repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..102423	102423

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Antitoxin

• Toxin YoeB (5-84)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9362.53 Da
• Isoelectric Point: 4.7672

>T150142 WP_163836097.1 NZ_CP048880:21344-21598 [Spartinivicinus ruber]
MDTISYSAFRSKLAGTLDKVNDDHTPVLITRQNGKPAVLMSLEDFKSYEATAYLMASQRNAERLNQAIAQVEDGKTVERG
LIEE

Nucleotide

• Length: 255 bp

>T150142 NZ_CP064395:1907598-1908185 [Pseudomonas aeruginosa]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGTTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGGCGTTGCCGCTCGCCGTCCGCCTCGGCGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAGTTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGCGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 10291.79 Da
• Isoelectric Point: 8.8305

>AT150142 WP_163836100.1 NZ_CP048880:21595-21849 [Spartinivicinus ruber]
MILSWAELAWEDYLYWQQTDKKTLKRINTLIKDIKHQPFDGLGDPEPLKHNWSGYWSRRIDREHRLVYKVTDTAIIVVQC
RYHY

Nucleotide

• Length: 255 bp

>AT150142 NZ_CP064395:1908252-1909106 [Pseudomonas aeruginosa]
GTGCCGGACGAGACGAGCGGAGAACACACGCATTTCTGGCGCGCCGCCGAACTGGGCGGCGTCGAACTGCTGCACGCGCG
CTATGTGGAGCAGCGCTTCGCGCCGCACGTGCACAGCAGCTTCGCCCTGGTCATCATCGAGCAGGGCGCGCAGCGCTTCC
GCCATCGTGGCGGCGAGCACCTGGCCCCGCTGGGCAGCATGGTGCTGATCAACCCCGACGAAGTGCACACCGGCTCCAAG
GCCCATGATGCCGGTTGGCTCTATCGCGGCTACTACCCGGAAATGGAACAGATCGACGGGATTCTCGACGAGCTGGAAAT
CCATCATGGCGGTGTGCCGCGCTTCGCCGACAGCGTGATCCACGACCAGCCCCTGGCACGCGCCTTCGTCCACTTGCACC
GCCTGCTGGCCGAGCATGCCGGCAGCCTGGAAACCCAGACCCGCTGGCGCGAGACGGTGCTCGCCCTGTTCCGTCGCCAC
GCCCGCCTGCCAGAAGCGCCGAAGGCCGGGCAGGAGCCGTTGGCGGTGGCCCGTGCCCGCGAACTGCTGGCGGCGCGGTT
GCTCGATCCGCCTTCGCTGGAGGAACTGGCGGCGGCGGTCAATCTGTCCCCGTTCCATTTTGCCCGGGTCTTCCGTCGCG
CCACCGGCATGCCGCCCCACGCCTGGCTCAGGCAGCGCCGCCTGGAGCAGGCCAGGGCACTGCTCAAGAGCGGCCGGGCG
CCGCTGGAGGTGGCCCTGGAGCTGGGCTTCGCCGACCAGAGCCACCTCGGTCGCCAGTTCAAGCAGGCCTACGGCGTGGC
ACCGGGTGAATACCGCTCGGCCTGCGCGCGCTCATCCTTGACGATCTACGAATAA