Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 19691..20337 Replicon plasmid pB
Accession NZ_CP048880
Organism Spartinivicinus ruber strain S2-4-1H

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag G4Y78_RS29520 Protein ID WP_163836103.1
Coordinates 19924..20337 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag G4Y78_RS29515 Protein ID WP_163836104.1
Coordinates 19691..19924 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G4Y78_RS29495 15690..17012 + 1323 WP_163836812.1 hypothetical protein -
G4Y78_RS29500 17172..18410 - 1239 WP_163836813.1 ATP-binding protein -
G4Y78_RS29505 19021..19230 + 210 WP_163836913.1 cold-shock protein -
G4Y78_RS29510 19278..19577 - 300 WP_163836814.1 helix-turn-helix domain-containing protein -
G4Y78_RS29515 19691..19924 + 234 WP_163836104.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
G4Y78_RS29520 19924..20337 + 414 WP_163836103.1 type II toxin-antitoxin system VapC family toxin Toxin
G4Y78_RS29525 20367..20549 + 183 WP_163836815.1 hypothetical protein -
G4Y78_RS29530 20577..21233 - 657 WP_163836101.1 type II toxin-antitoxin system HicB family antitoxin -
G4Y78_RS29535 21344..21598 + 255 WP_163836097.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
G4Y78_RS29540 21595..21849 + 255 WP_163836100.1 Txe/YoeB family addiction module toxin -
G4Y78_RS29545 22288..22554 + 267 WP_163836099.1 hypothetical protein -
G4Y78_RS29550 22544..22924 + 381 WP_163836098.1 type II toxin-antitoxin system VapC family toxin -
G4Y78_RS29555 23140..23646 - 507 WP_163836816.1 N-acetyltransferase -
G4Y78_RS29560 23917..24150 + 234 WP_163836817.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..102423 102423


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-127)

Antitoxin

SpoVT-AbrB domain

(9-54)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15369.67 Da        Isoelectric Point: 6.8606

>T150141 WP_163836103.1 NZ_CP048880:19924-20337 [Spartinivicinus ruber]
MLYMLDTDMCSYIIRKRPISVLETLQKQSEFGASICISAITYAELLLGAERSQAREKHLNLIHGLIERIDKVLPWNAQAA
ESFSTLQAYLFSQGTPIGSNDTMIAGHALSVDAMLVTNNQRHFSKVPDIKLDNWNSK

Download         Length: 414 bp

>T150141 NZ_CP064395:1637132-1638001 [Pseudomonas aeruginosa]
ATGAACATGGCGCAGACCCACACCCCCGTCCCGAACCTGCAACAGCGCTTTCCCGAGCGGCTGGTGCAACTGGCCGACGG
CGCCCAGCTGGCCATCCGCGAATGCGGCCAGGGCCCGGTGGTGGTGCTGTTGCACGGCATCGGTTCGGGCTCGGCGTCCT
GGCTGCATTGCGCCCAGCGCCTGGCCGCCGGCAATCGGGTGATCGCCTGGGACGCGCCGGGTTACGGCCTGTCCACGCCG
CTGCCGCCGGCCCGGCCCAAGGCCTGCGACTACGCCGCGTGCCTGGAGCTGCTGCTGGATGCGCTGGGCGTGGAGAGCTG
CCTGCTGGTGGGCCACTCCCTCGGCGCGCTGATGGCCACGGCCTACGCCGCCGGCATCGGCGCGGCGCGGGTGCGCCGCC
TGGTGCTGCTCAGCCCGGCGCGCGGCTACGGCGCCGCCGAGCTGCGCGACAGCGGCGCCCAGGTGCGCCGCCAGCGCCTG
GAGAACCTGGAGCGCTTCGGTATCGACGGCATGGCCAGCGAGCGCACCGCGCGCCTGCTCGGCCGCAACCCCAGCGAGGA
GGCCCTGGCCTGGGTGCGCTGGAACATGGCGCGGCTCAACCCCGAGGGCTACCGCCAGGCCGTCGAGCTGCTCTGCGGCG
ACGACCTGCTGGGCAACGGGCAGCCTGCCGCTCCTTGCGAGGTGCATTGCGGCGAGGACGACGGCATCACCACGCCCGAG
AGTTGCGGCGCCATCGCCCGCCAGCTCGGCGCGTCGTTCTCGTCGATTCCCGGGGCCGGCCACGCCAGCCCGATCGAACA
ACCCGAAGTGGTCGCAGGACGCATCGGCCACGCGCAACGCCTCTCTCTTGAAGGAACCGCCAATGGATAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8912.19 Da        Isoelectric Point: 4.8011

>AT150141 WP_163836104.1 NZ_CP048880:19691-19924 [Spartinivicinus ruber]
MPDRTAKLFTNGRNQAVRLPKMFEFSGIDEVFIRKEGDSIILTPKRKSWLSFAELPAADDDFMAERADIMETNRVEF

Download         Length: 234 bp

>AT150141 NZ_CP064395:1637994-1638827 [Pseudomonas aeruginosa]
ATGGATAAGTCAGACGATTCGCAAGACAAGTACATCGTGCCTGGCCTCGAACGCGGCCTGCTGCTGCTCTGCGAGTTCAG
CCGGAAGGACCGTACCCTGACGGCGCCGGAGTTGGCGCGGCGCCTGAAGCTGCCGCGCTCGACCATCTTCCGCCTGCTGA
CCACCCTGGAGGCCATGGGCTTCGTCACCCGCAACGGCAACGAGTACCGCCTGGGCATGGCGGTGTTGCGCCTGGGCTTC
GAGTACCTGGCCTCGCTGGAGCTGACCGAACTCGGCCAGCCGCTGCTGAACCGCCTGTGCGACGAGATCCGCTACCCCTG
CAACCTGGTGGTGCGCGACGGCCGTTCGATCGTCTACGTGGCCAAGGTTTCGCCGTCCACCCCGCTGAGCAGCTCGGTGA
ACGTCGGGACCCGGTTGCCGGCCCACGCCACGGTGCTCGGCCGCATCCTGCTGCAGGACCTGAGCCTGGGCGAGCTGCGC
GAGCTGTACCCGGAGGAGCAGCTGGAGCAGTTCTCGCCGAACACCCCGCGCAGCGTGCTGGAACTCTTCGACATGGTCCA
GGGCGACCGCCAGCGTGGCTTCGTCCAGGGCGAGGGGTTCTTCGAGGCGAGCATCTCCACCGTCGCGGCGCCGGTACGTG
ATCACAGCGGTCGCGTCATCGCGGCGATGGGGGCGACCATCGCCGCCGGGCATATCGACCCGGAACGCATCGAGGGACTG
GTCAGCCGGGTGCGCAGCAGCGCCGACGAGCTGTCGTACCTGCTCGACTACCGCGCCGACGGCCAGGACAACGTCACCCC
GATCTTCCGGAGTCGCCCGCATGAAACCGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References