Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 6042075..6042721 Replicon chromosome
Accession NZ_CP048878
Organism Spartinivicinus ruber strain S2-4-1H

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag G4Y78_RS27295 Protein ID WP_163836103.1
Coordinates 6042075..6042488 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag G4Y78_RS27300 Protein ID WP_163836104.1
Coordinates 6042488..6042721 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G4Y78_RS27250 6037328..6037582 - 255 WP_163836096.1 Txe/YoeB family addiction module toxin -
G4Y78_RS27255 6037579..6037833 - 255 WP_163836097.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
G4Y78_RS27260 6038076..6039356 - 1281 WP_163836066.1 ISL3 family transposase -
G4Y78_RS27265 6039488..6039868 - 381 WP_163836098.1 type II toxin-antitoxin system VapC family toxin -
G4Y78_RS27270 6039858..6040124 - 267 WP_163836099.1 hypothetical protein -
G4Y78_RS27275 6040563..6040817 - 255 WP_163836100.1 Txe/YoeB family addiction module toxin -
G4Y78_RS27280 6040814..6041068 - 255 WP_163836097.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
G4Y78_RS27285 6041179..6041835 + 657 WP_163836101.1 type II toxin-antitoxin system HicB family antitoxin -
G4Y78_RS27290 6041863..6042045 - 183 WP_163836102.1 hypothetical protein -
G4Y78_RS27295 6042075..6042488 - 414 WP_163836103.1 type II toxin-antitoxin system VapC family toxin Toxin
G4Y78_RS27300 6042488..6042721 - 234 WP_163836104.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
G4Y78_RS27305 6042835..6043074 + 240 WP_163836105.1 hypothetical protein -
G4Y78_RS27310 6043091..6044371 + 1281 WP_163836066.1 ISL3 family transposase -
G4Y78_RS27315 6044514..6045359 + 846 WP_163836088.1 transporter substrate-binding domain-containing protein -
G4Y78_RS27320 6045382..6046152 + 771 WP_163836069.1 transporter substrate-binding domain-containing protein -
G4Y78_RS27325 6046406..6047014 + 609 WP_163836106.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - pilM / pilJ / pilH / pilG / pilU / pilT 5758046..6217034 458988


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-127)

Antitoxin

SpoVT-AbrB domain

(9-54)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15369.67 Da        Isoelectric Point: 6.8606

>T150139 WP_163836103.1 NZ_CP048878:c6042488-6042075 [Spartinivicinus ruber]
MLYMLDTDMCSYIIRKRPISVLETLQKQSEFGASICISAITYAELLLGAERSQAREKHLNLIHGLIERIDKVLPWNAQAA
ESFSTLQAYLFSQGTPIGSNDTMIAGHALSVDAMLVTNNQRHFSKVPDIKLDNWNSK

Download         Length: 414 bp

>T150139 NZ_CP064393:c5765774-5765496 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTTGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8912.19 Da        Isoelectric Point: 4.8011

>AT150139 WP_163836104.1 NZ_CP048878:c6042721-6042488 [Spartinivicinus ruber]
MPDRTAKLFTNGRNQAVRLPKMFEFSGIDEVFIRKEGDSIILTPKRKSWLSFAELPAADDDFMAERADIMETNRVEF

Download         Length: 234 bp

>AT150139 NZ_CP064393:c5765484-5765179 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References