Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 3685327..3685980 Replicon chromosome
Accession NZ_CP048849
Organism Acinetobacter baumannii strain D4

Toxin (Protein)


Gene name cptA Uniprot ID A0A3R9G864
Locus tag AbD4_RS17550 Protein ID WP_000607075.1
Coordinates 3685327..3685716 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag AbD4_RS17555 Protein ID WP_001288210.1
Coordinates 3685723..3685980 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AbD4_RS17535 (AbD4_03536) 3680445..3682640 - 2196 WP_001158905.1 TRAP transporter large permease subunit -
AbD4_RS17540 (AbD4_03537) 3682828..3683394 - 567 WP_000651539.1 rhombosortase -
AbD4_RS17545 (AbD4_03538) 3683472..3684557 - 1086 WP_000049106.1 hypothetical protein -
AbD4_RS17550 (AbD4_03540) 3685327..3685716 - 390 WP_000607075.1 membrane protein Toxin
AbD4_RS17555 (AbD4_03541) 3685723..3685980 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
AbD4_RS17560 (AbD4_03542) 3686168..3687340 + 1173 WP_001190556.1 acyl-CoA dehydrogenase family protein -
AbD4_RS17565 (AbD4_03543) 3687389..3688879 - 1491 WP_000415123.1 NAD(P)/FAD-dependent oxidoreductase -
AbD4_RS17570 (AbD4_03544) 3689061..3689438 - 378 WP_001216380.1 50S ribosomal protein L17 -
AbD4_RS17575 (AbD4_03545) 3689457..3690464 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15649.94 Da        Isoelectric Point: 10.3890

>T150113 WP_000607075.1 NZ_CP048849:c3685716-3685327 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKVIDYQIFIVIYFEGHKTLTSIIWFDQMSLVEWKKLKTLEKLY

Download         Length: 390 bp

>T150113 NZ_CP064389:1762672-1763136 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGTACTC
ACTACGGCGAATTCTCAATTACATTTGAGCCGTTGAGAGTTTTTAAATTGCATCATATTGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT150113 WP_001288210.1 NZ_CP048849:c3685980-3685723 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT150113 NZ_CP064389:1762345-1762659 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R9G864

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References