Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 3146086..3146651 Replicon chromosome
Accession NZ_CP048838
Organism [Clostridium] innocuum strain ATCC 14501

Toxin (Protein)


Gene name relE Uniprot ID C7H6P5
Locus tag G4D54_RS15355 Protein ID WP_002596328.1
Coordinates 3146361..3146651 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C7H6P4
Locus tag G4D54_RS15350 Protein ID WP_005924829.1
Coordinates 3146086..3146364 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G4D54_RS15310 3141574..3141789 - 216 WP_000394208.1 Maff2 family protein -
G4D54_RS15315 3141793..3142104 - 312 WP_000807045.1 hypothetical protein -
G4D54_RS15320 3142272..3143054 - 783 WP_210548309.1 TraM recognition domain-containing protein -
G4D54_RS15325 3143171..3143536 - 366 WP_055195003.1 hypothetical protein -
G4D54_RS15330 3143615..3143809 - 195 WP_002596333.1 transposon-encoded TnpW family protein -
G4D54_RS15335 3143853..3144716 - 864 WP_168389016.1 ATP-binding protein -
G4D54_RS15340 3144713..3145447 - 735 WP_168389017.1 phage replisome organizer N-terminal domain-containing protein -
G4D54_RS15345 3145561..3145959 - 399 WP_112148958.1 cysteine-rich VLP domain-containing protein -
G4D54_RS15350 3146086..3146364 + 279 WP_005924829.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
G4D54_RS15355 3146361..3146651 + 291 WP_002596328.1 type II toxin-antitoxin system YafQ family toxin Toxin
G4D54_RS15360 3146759..3148204 - 1446 WP_168389018.1 MobA/MobL family protein -
G4D54_RS15365 3148391..3148681 - 291 WP_062808218.1 DUF3847 domain-containing protein -
G4D54_RS15370 3148710..3149171 - 462 WP_015528452.1 sigma-70 family RNA polymerase sigma factor -
G4D54_RS15375 3149182..3149634 - 453 WP_168389073.1 RNA polymerase subunit sigma-24 -
G4D54_RS15380 3149738..3150151 - 414 WP_168389019.1 sigma-70 family RNA polymerase sigma factor -
G4D54_RS15385 3150629..3151000 - 372 WP_168389074.1 metal-dependent transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3069902..3186457 116555


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-94)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-90)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11112.87 Da        Isoelectric Point: 8.0630

>T150112 WP_002596328.1 NZ_CP048838:3146361-3146651 [[Clostridium] innocuum]
MKETKYTVKYTTSFKKDYKRAIKRGLKIELLEQVVALLAMGEPLPDKNRDHDLSGDWAGHRECHILPDWLLVYRIEDDVL
VLTLARTGTHSDLFGK

Download         Length: 291 bp

>T150112 NZ_CP064389:878589-878741 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10247.66 Da        Isoelectric Point: 4.4692

>AT150112 WP_005924829.1 NZ_CP048838:3146086-3146364 [[Clostridium] innocuum]
MAGNTTNISIRMDADLKAQADALFTELGMNLTTAFNIFVRQSLREGGIPFEVRLEQPNKETVAAMLEAERIAKDPSVKGY
NDLDELFADLKR

Download         Length: 279 bp

>AT150112 NZ_CP064389:877965-878564 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M4XBM1

Antitoxin

Source ID Structure
AlphaFold DB A0A1M4XB19

References