Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 3146086..3146651 Replicon chromosome
Accession NZ_CP048838
Organism [Clostridium] innocuum strain ATCC 14501

Toxin (Protein)


Gene name relE Uniprot ID C7H6P5
Locus tag G4D54_RS15355 Protein ID WP_002596328.1
Coordinates 3146361..3146651 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C7H6P4
Locus tag G4D54_RS15350 Protein ID WP_005924829.1
Coordinates 3146086..3146364 (+) Length 93 a.a.

Genomic Context

G4D54_RS15350G4D54_RS15355G4D54_RS15310G4D54_RS15315G4D54_RS15320G4D54_RS15325G4D54_RS15330G4D54_RS15335G4D54_RS15340G4D54_RS15345G4D54_RS15360G4D54_RS15365G4D54_RS15370G4D54_RS15375G4D54_RS15380G4D54_RS15385
Location: 3146086..3146364 (279 bp)
Type: Antitoxin
Protein ID: WP_005924829.1
Location: 3146361..3146651 (291 bp)
Type: Toxin
Protein ID: WP_002596328.1
Location: 3141574..3141789 (216 bp)
Type: Others
Protein ID: WP_000394208.1
Location: 3141793..3142104 (312 bp)
Type: Others
Protein ID: WP_000807045.1
Location: 3142272..3143054 (783 bp)
Type: Others
Protein ID: WP_210548309.1
Location: 3143171..3143536 (366 bp)
Type: Others
Protein ID: WP_055195003.1
Location: 3143615..3143809 (195 bp)
Type: Others
Protein ID: WP_002596333.1
Location: 3143853..3144716 (864 bp)
Type: Others
Protein ID: WP_168389016.1
Location: 3144713..3145447 (735 bp)
Type: Others
Protein ID: WP_168389017.1
Location: 3145561..3145959 (399 bp)
Type: Others
Protein ID: WP_112148958.1
Location: 3146759..3148204 (1446 bp)
Type: Others
Protein ID: WP_168389018.1
Location: 3148391..3148681 (291 bp)
Type: Others
Protein ID: WP_062808218.1
Location: 3148710..3149171 (462 bp)
Type: Others
Protein ID: WP_015528452.1
Location: 3149182..3149634 (453 bp)
Type: Others
Protein ID: WP_168389073.1
Location: 3149738..3150151 (414 bp)
Type: Others
Protein ID: WP_168389019.1
Location: 3150629..3151000 (372 bp)
Type: Others
Protein ID: WP_168389074.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
G4D54_RS153103141574..3141789-216WP_000394208.1Maff2 family protein-
G4D54_RS153153141793..3142104-312WP_000807045.1hypothetical protein-
G4D54_RS153203142272..3143054-783WP_210548309.1TraM recognition domain-containing protein-
G4D54_RS153253143171..3143536-366WP_055195003.1hypothetical protein-
G4D54_RS153303143615..3143809-195WP_002596333.1transposon-encoded TnpW family protein-
G4D54_RS153353143853..3144716-864WP_168389016.1ATP-binding protein-
G4D54_RS153403144713..3145447-735WP_168389017.1phage replisome organizer N-terminal domain-containing protein-
G4D54_RS153453145561..3145959-399WP_112148958.1cysteine-rich VLP domain-containing protein-
G4D54_RS153503146086..3146364+279WP_005924829.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
G4D54_RS153553146361..3146651+291WP_002596328.1type II toxin-antitoxin system YafQ family toxinToxin
G4D54_RS153603146759..3148204-1446WP_168389018.1MobA/MobL family protein-
G4D54_RS153653148391..3148681-291WP_062808218.1DUF3847 domain-containing protein-
G4D54_RS153703148710..3149171-462WP_015528452.1sigma-70 family RNA polymerase sigma factor-
G4D54_RS153753149182..3149634-453WP_168389073.1RNA polymerase subunit sigma-24-
G4D54_RS153803149738..3150151-414WP_168389019.1sigma-70 family RNA polymerase sigma factor-
G4D54_RS153853150629..3151000-372WP_168389074.1metal-dependent transcriptional regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegrative and Conjugative Element--3069902..3186457116555


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-94)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-90)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11112.87 Da        Isoelectric Point: 8.0630

>T150112 WP_002596328.1 NZ_CP048838:3146361-3146651 [[Clostridium] innocuum]
MKETKYTVKYTTSFKKDYKRAIKRGLKIELLEQVVALLAMGEPLPDKNRDHDLSGDWAGHRECHILPDWLLVYRIEDDVL
VLTLARTGTHSDLFGK

Download         Length: 291 bp

>T150112 NZ_CP064389:878589-878741 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10247.66 Da        Isoelectric Point: 4.4692

>AT150112 WP_005924829.1 NZ_CP048838:3146086-3146364 [[Clostridium] innocuum]
MAGNTTNISIRMDADLKAQADALFTELGMNLTTAFNIFVRQSLREGGIPFEVRLEQPNKETVAAMLEAERIAKDPSVKGY
NDLDELFADLKR

Download         Length: 279 bp

>AT150112 NZ_CP064389:877965-878564 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1M4XBM1

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1M4XB19

References