Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2709820..2710490 Replicon chromosome
Accession NZ_CP048836
Organism Azoarcus sp. M9-3-2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G3580_RS12505 Protein ID WP_173765996.1
Coordinates 2710047..2710490 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G3580_RS12500 Protein ID WP_173765994.1
Coordinates 2709820..2710050 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G3580_RS12475 2705411..2706103 + 693 WP_173765984.1 flagellar basal body P-ring formation protein FlgA -
G3580_RS12480 2706232..2706537 + 306 WP_173765986.1 flagellar biosynthesis anti-sigma factor FlgM -
G3580_RS12485 2706534..2707010 + 477 WP_173765988.1 flagellar protein FlgN -
G3580_RS12490 2707040..2707684 + 645 WP_173765990.1 HD domain-containing protein -
G3580_RS12495 2707786..2709765 + 1980 WP_173765992.1 type IIA DNA topoisomerase subunit B -
G3580_RS12500 2709820..2710050 + 231 WP_173765994.1 antitoxin Antitoxin
G3580_RS12505 2710047..2710490 + 444 WP_173765996.1 type II toxin-antitoxin system VapC family toxin Toxin
G3580_RS12510 2710487..2712841 + 2355 WP_173765998.1 DNA topoisomerase IV subunit A -
G3580_RS12515 2713017..2713676 + 660 WP_173768794.1 2OG-Fe(II) oxygenase -
G3580_RS12520 2713743..2714219 - 477 WP_173765999.1 bacteriohemerythrin -
G3580_RS12525 2714322..2715167 - 846 WP_173766001.1 flagellar motor protein MotD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(7-42)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16318.41 Da        Isoelectric Point: 6.2164

>T150111 WP_173765996.1 NZ_CP048836:2710047-2710490 [Azoarcus sp. M9-3-2]
VRYMLDTNICIYLINHRPTHVRSRFDAHSVGEIGVSTITAMELAYGVERSGSARNRQALETFLLPLEIAPFDEAAIGHYA
RIRHQLEQRGTPIGPYDLQIAAHARALGCTLVTNNTRAFERVDDLLIENWAEQGVSEPPASYLGTSA

Download         Length: 444 bp

>T150111 NZ_CP064389:772693-772869 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8679.92 Da        Isoelectric Point: 5.1053

>AT150111 WP_173765994.1 NZ_CP048836:2709820-2710050 [Azoarcus sp. M9-3-2]
MDTAKLFINGRSQAVRLPKEFRFEGDEVFIKRVGDAVVLLPRHGWKTLFDGLEAFEAGFAIEREQPSMQTREALDP

Download         Length: 231 bp

>AT150111 NZ_CP064389:c773031-772857 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References