Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 4084439..4085004 Replicon chromosome
Accession NZ_CP048835
Organism Streptomyces sp. So13.3

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag C8250_RS18440 Protein ID WP_138356576.1
Coordinates 4084439..4084810 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag C8250_RS18445 Protein ID WP_138356575.1
Coordinates 4084807..4085004 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C8250_RS18425 4079823..4081457 - 1635 WP_138356578.1 hypothetical protein -
C8250_RS18430 4081906..4082436 + 531 WP_138356577.1 hypothetical protein -
C8250_RS18435 4082502..4084292 - 1791 WP_138356625.1 DEAD/DEAH box helicase -
C8250_RS18440 4084439..4084810 - 372 WP_138356576.1 Fic family protein Toxin
C8250_RS18445 4084807..4085004 - 198 WP_138356575.1 hypothetical protein Antitoxin
C8250_RS18450 4085038..4085697 - 660 Protein_3666 MFS transporter -
C8250_RS18460 4086033..4088354 - 2322 WP_138356574.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
C8250_RS18465 4088449..4089819 - 1371 WP_138356573.1 (2Fe-2S)-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(7-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13750.75 Da        Isoelectric Point: 5.7034

>T150108 WP_138356576.1 NZ_CP048835:c4084810-4084439 [Streptomyces sp. So13.3]
VTYYLTLPEILNLAKRLGADEVRDYGLLDSALARPRATVFGQDAYPDIWHKAAALMESLARNRALVDGNKRIAWYATWVF
LQINGHTLRAGFDVDEAETFVLNVCQGVLDVPKTAEILPRFTG

Download         Length: 372 bp

>T150108 NZ_CP064389:652994-653203 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7235.09 Da        Isoelectric Point: 4.5469

>AT150108 WP_138356575.1 NZ_CP048835:c4085004-4084807 [Streptomyces sp. So13.3]
MPGLNVRFTDDELEALRERAEAESTSMQVIAHDAVVRAISERARLFEAAATHVLQASEELNQRLA

Download         Length: 198 bp

>AT150108 NZ_CP064389:652689-652982 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References