Detailed information of TA system TA150107

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 6286673..6287286
• Replicon: chromosome
• Accession: NZ_CP048833
• Organism: Pseudomonas multiresinivorans strain populi

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: G4G71_RS28670
• Protein ID: WP_169942134.1
• Coordinates: 6286673..6286855 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: G4G71_RS28675
• Protein ID: WP_169942136.1
• Coordinates: 6286879..6287286 (+)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G4G71_RS28650	6282491..6283054	-	564	WP_169942126.1	SEC-C domain-containing protein	-
G4G71_RS28655	6283171..6283947	-	777	WP_169942128.1	deoxyribose-phosphate aldolase	-
G4G71_RS28660	6284084..6285559	-	1476	WP_169942130.1	AMP nucleosidase	-
G4G71_RS28665	6286083..6286589	+	507	WP_169942132.1	Bro-N domain-containing protein	-
G4G71_RS28670	6286673..6286855	+	183	WP_169942134.1	type II toxin-antitoxin system HicA family toxin	Toxin
G4G71_RS28675	6286879..6287286	+	408	WP_169942136.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
G4G71_RS28680	6287317..6287659	-	343	Protein_5653	type II toxin-antitoxin system HicB family antitoxin	-
G4G71_RS28685	6287869..6289518	-	1650	WP_169942138.1	acyl-CoA dehydrogenase family protein	-
G4G71_RS28690	6289515..6290198	-	684	WP_169942141.1	TetR family transcriptional regulator	-
G4G71_RS28695	6290320..6291570	-	1251	WP_169942143.1	OprD family porin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6776.86 Da
• Isoelectric Point: 11.5631

>T150107 WP_169942134.1 NZ_CP048833:6286673-6286855 [Pseudomonas multiresinivorans]
VQNRELIKELEAAGWALQRITGSHHVFTHPNRSYSVPVPHPKKDLPIGTVRSIRKRAGLI

Nucleotide

• Length: 183 bp

>T150107 NZ_CP064389:595699-595803 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 14564.49 Da
• Isoelectric Point: 4.7330

>AT150107 WP_169942136.1 NZ_CP048833:6286879-6287286 [Pseudomonas multiresinivorans]
MQYPIAIEWGNDETAIGIHIPDIPGAVTAGDTYEEAYAAAVEVAHLMLEEIAGAGQEVPFPSSVAAHRSHPDFEGMGWGL
LEIDITPYLGKTEKVNVTLPGYIIQRIDNHVRLHGVKSRSSFLATAALEKLTRGA

Nucleotide

• Length: 408 bp

>AT150107 NZ_CP064389:c595962-595798 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT