Detailed information of TA system TA150104

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 2273261..2274394
• Replicon: chromosome
• Accession: NZ_CP048833
• Organism: Pseudomonas multiresinivorans strain populi

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: G4G71_RS10535
• Protein ID: WP_169937403.1
• Coordinates: 2273630..2274394 (+)
• Length: 255 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A1B8V7T7
• Locus tag: G4G71_RS10530
• Protein ID: WP_024763405.1
• Coordinates: 2273261..2273629 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G4G71_RS10490	2268492..2268740	+	249	WP_024763399.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
G4G71_RS10495	2268747..2269088	+	342	WP_169937389.1	type II toxin-antitoxin system RelE/ParE family toxin	-
G4G71_RS10500	2269440..2270312	-	873	WP_169937391.1	methyltransferase domain-containing protein	-
G4G71_RS10505	2270537..2270905	-	369	WP_169942605.1	hypothetical protein	-
G4G71_RS10510	2271004..2271351	-	348	WP_169937394.1	carboxymuconolactone decarboxylase family protein	-
G4G71_RS10515	2271485..2271967	-	483	WP_169937396.1	GreA/GreB family elongation factor	-
G4G71_RS10520	2272092..2272526	+	435	WP_169937398.1	hypothetical protein	-
G4G71_RS10525	2272533..2272991	-	459	WP_169937400.1	RcnB family protein	-
G4G71_RS10530	2273261..2273629	+	369	WP_024763405.1	DUF2384 domain-containing protein	Antitoxin
G4G71_RS10535	2273630..2274394	+	765	WP_169937403.1	RES family NAD+ phosphorylase	Toxin
G4G71_RS10540	2274472..2274681	+	210	WP_169937405.1	hypothetical protein	-
G4G71_RS10545	2275252..2276616	+	1365	WP_169942607.1	DNA recombination protein RmuC	-
G4G71_RS10550	2276766..2278112	-	1347	WP_169937407.1	FAD-binding oxidoreductase	-
G4G71_RS10555	2278201..2279091	-	891	WP_045210331.1	metal-dependent hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (68-210)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (10-67)

Sequences

Toxin

Protein

• Length: 255 a.a.
• Molecular weight: 28887.10 Da
• Isoelectric Point: 8.4428

>T150104 WP_169937403.1 NZ_CP048833:2273630-2274394 [Pseudomonas multiresinivorans]
MSFEAGARLWAKYEDSVVAPIRGRLVRLVESQGQVATLQLVDTLEEQALLEELLETSKPRMPPSAEPLHYLLKTPFRYPP
LRWGSRFGRRHEPSLFYGALKLETAMAESAFYRFVLWEGMATPPPSGRILSEHASFEARFQVQKGVRLHLPPFREHAALL
DPQDYSVTQGMGSAMRDAGVEAFEYRSARCPQGGINVALFVPSAFTEKRPRNLMPWLCETTSEYVAFKHAQVPDSPRIYR
REQYLVDGRLPHPA

Nucleotide

• Length: 765 bp

>T150104 NZ_CP064389:273603-273869 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13515.77 Da
• Isoelectric Point: 10.1440

>AT150104 WP_024763405.1 NZ_CP048833:2273261-2273629 [Pseudomonas multiresinivorans]
MSALLKENPAADTVLAKAVLTAREHLAMTQQELAAIVGVDRSAVSRWKQNGLRVDSKTGELALLLVRIYRALFALFGGNH
EDMRHFLRTENRHLGGVPLQLMERVQGLVAVVEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT150104 NZ_CP064389:273346-273603 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A1B8V7T7