Detailed information of TA system TA150102

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 1784407..1784954
• Replicon: chromosome
• Accession: NZ_CP048833
• Organism: Pseudomonas multiresinivorans strain populi

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A0F0DXH2
• Locus tag: G4G71_RS08150
• Protein ID: WP_045211087.1
• Coordinates: 1784407..1784694 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: G4G71_RS08155
• Protein ID: WP_169936694.1
• Coordinates: 1784685..1784954 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G4G71_RS08125	1779543..1780448	+	906	WP_169936686.1	LysR family transcriptional regulator	-
G4G71_RS08130	1780560..1781135	+	576	WP_169936688.1	YceI family protein	-
G4G71_RS08135	1781132..1782289	+	1158	WP_169936690.1	phosphatidylserine/phosphatidylglycerophosphate/ cardiolipin synthase family protein	-
G4G71_RS08140	1782322..1783614	+	1293	WP_169936692.1	acyltransferase	-
G4G71_RS08145	1783812..1784399	+	588	WP_169942556.1	GNAT family acetyltransferase	-
G4G71_RS08150	1784407..1784694	-	288	WP_045211087.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G4G71_RS08155	1784685..1784954	-	270	WP_169936694.1	ribbon-helix-helix protein, CopG family	Antitoxin
G4G71_RS08160	1785142..1785720	+	579	WP_037014955.1	DUF2846 domain-containing protein	-
G4G71_RS08165	1786048..1786560	+	513	WP_169936696.1	formaldehyde-activating enzyme	-
G4G71_RS08170	1786571..1787605	+	1035	WP_169936698.1	aldo/keto reductase	-
G4G71_RS08175	1787602..1789041	+	1440	WP_169936700.1	NAD-dependent succinate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-93)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-39)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10944.59 Da
• Isoelectric Point: 9.4963

>T150102 WP_045211087.1 NZ_CP048833:c1784694-1784407 [Pseudomonas multiresinivorans]
MRVIYAPAALRDLDRLRRFLRETNPTAARRAGQIILQATQALGAYPQMGRLIDDLPIEFREWPIDFGDSGYIARYRIDGE
TLVILAIRHQREAGY

Nucleotide

• Length: 288 bp

>T150102 NZ_CP064388:21176-21577 [Escherichia coli O104:H4]
ATGCTCGACACGAATATCTGCTCTTTCATTATGCGTGAACAGCCCGCCGCAGTGATCAAACGTCTGGAGCAGGCGGTGCT
GCGTAACCACCGCATTGTCGTGTCGGCCATCACCTATGCGGAGATGCGTTTCGACGCCACCGGCCCGAAAGCCTCACCGC
GTCATATTGCGCTGGTTGACGCGTTCTGCGCCCGCCTCGATGCCATTCTGCCCTGGGACCGCGCTGCCGTGGACGCCACC
ACGGAGATTAAAATGGCACTGCGGCTGGCCGAGACGCCAATCGGCCCGAACAACACGGCGATTGCCGGGCACGCCATCGC
TGCCGGGGCGATACTGGTGACGAATAATACAAGAGAGTTTGAGCGGGTGCCTGACCTGGTGCTGGAAGACTGGGTGAAGT
AA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10442.59 Da
• Isoelectric Point: 4.4422

>AT150102 WP_169936694.1 NZ_CP048833:c1784954-1784685 [Pseudomonas multiresinivorans]
MATSVKLDEEMLARVRELAELRQRSPHWIMREAIGQYVVREEQREKLKRDTEQAWEEFQATGQHVAAEAVESWLNSWGDE
DEQAAPKCE

Nucleotide

• Length: 270 bp

>AT150102 NZ_CP064388:20922-21152 [Escherichia coli O104:H4]
ATGAGAACCGTATCGATATTTAAAAATGGCAACAACCGCGCCATCCGTCTGCCCCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTTGAGATCGTCCGCGAAGGAGACAGCATTATATTGCGCCCGGTCCGGCCGACCTGGAGCTCGTTTGCGGCACTCG
AAAAGGCCGACGCAGACTTTATGGCGGAGCGTGAGGACATTGTCAGCGACGAAGGAAGATTTGACCTGTGA

Structures

Toxin

• AlphaFold DB: A0A0F0DXH2