Detailed information of TA system TA150097

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/StbC(antitoxin)
• Location: 1314544..1315173
• Replicon: chromosome
• Accession: NZ_CP048832
• Organism: Janthinobacterium lividum strain EIF1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: G3257_RS05900
• Protein ID: WP_176374738.1
• Coordinates: 1314757..1315173 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A1G8GYN1
• Locus tag: G3257_RS05895
• Protein ID: WP_034784992.1
• Coordinates: 1314544..1314753 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G3257_RS05875	1310304..1311383	-	1080	WP_176374736.1	alpha/beta hydrolase	-
G3257_RS05880	1311888..1313126	+	1239	WP_034784989.1	bifunctional glutamate N-acetyltransferase/amino-acid acetyltransferase ArgJ	-
G3257_RS05885	1313123..1314004	+	882	WP_176374737.1	ATP-binding protein	-
G3257_RS05890	1314001..1314423	+	423	WP_070258873.1	NUDIX domain-containing protein	-
G3257_RS05895	1314544..1314753	+	210	WP_034784992.1	hypothetical protein	Antitoxin
G3257_RS05900	1314757..1315173	+	417	WP_176374738.1	VapC toxin family PIN domain ribonuclease	Toxin
G3257_RS05905	1315177..1315368	-	192	WP_034785391.1	DNA gyrase inhibitor YacG	-
G3257_RS05910	1315387..1316142	-	756	WP_034748811.1	cell division protein ZapD	-
G3257_RS05915	1316205..1316852	-	648	WP_176374739.1	dephospho-CoA kinase	-
G3257_RS05920	1316887..1317756	-	870	WP_176374740.1	A24 family peptidase	-
G3257_RS05925	1317862..1319058	-	1197	WP_176374741.1	type II secretion system F family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (19-117)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 14874.17 Da
• Isoelectric Point: 5.6436

>T150097 WP_176374738.1 NZ_CP048832:1314757-1315173 [Janthinobacterium lividum]
MPAYLVDTDVIVAGRKGGAAPAGVLDFFERVAPEMRYVPVQVIAQLRAGIQRSWRREAALEALALEGWLEAVLAEYAPRL
LEFDLDCALVCARLHARGHAHGVDGQIAAMGIAYGLTVVSGRLDSFAAQGLRLENPFS

Nucleotide

• Length: 417 bp

>T150097 NZ_CP064387:c4450206-4449829 [Escherichia coli O104:H4]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCATCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 7936.07 Da
• Isoelectric Point: 6.8798

>AT150097 WP_034784992.1 NZ_CP048832:1314544-1314753 [Janthinobacterium lividum]
MPLTLTFTDTDELLIAALHKRARAHGRSIEDEHRDILRSALRPLPKRPLDDILRGMPDVGHDADFERRP

Nucleotide

• Length: 210 bp

>AT150097 NZ_CP064387:c4450630-4450253 [Escherichia coli O104:H4]
GTGTCAGACACACTCCCCGGGACAACGCCTCCCGACGACAATCACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGAAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCATGACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAACCACCGTATAA

Structures

Antitoxin

• AlphaFold DB: A0A1G8GYN1