Detailed information of TA system TA150093

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2298406..2299085
• Replicon: chromosome
• Accession: NZ_CP048827
• Organism: Acinetobacter baumannii strain ABF9692

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: G3R47_RS11135
• Protein ID: WP_000838146.1
• Coordinates: 2298903..2299085 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: G3R47_RS11130
• Protein ID: WP_000966688.1
• Coordinates: 2298406..2298810 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G3R47_RS11120	2297362..2297625	-	264	WP_001275792.1	hypothetical protein	-
G3R47_RS11125	2297627..2298307	-	681	WP_000721572.1	hypothetical protein	-
G3R47_RS11130	2298406..2298810	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
G3R47_RS11135	2298903..2299085	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
G3R47_RS11140	2299411..2299926	-	516	WP_038346477.1	hypothetical protein	-
G3R47_RS11145	2299996..2300913	-	918	WP_038346476.1	hypothetical protein	-
G3R47_RS11150	2301010..2302152	-	1143	WP_038348069.1	hypothetical protein	-
G3R47_RS11155	2302152..2302505	-	354	WP_015451444.1	hypothetical protein	-
G3R47_RS11160	2302574..2303017	-	444	WP_016654267.1	hypothetical protein	-
G3R47_RS11165	2302974..2303342	-	369	WP_020752909.1	hypothetical protein	-
G3R47_RS11170	2303314..2303724	-	411	WP_005124464.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2281261..2326329	45068

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T150093 WP_000838146.1 NZ_CP048827:c2299085-2298903 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T150093 NZ_CP064387:c3406198-3405887 [Escherichia coli O104:H4]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT150093 WP_000966688.1 NZ_CP048827:c2298810-2298406 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT150093 NZ_CP064387:c3405886-3405596 [Escherichia coli O104:H4]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTCAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6