Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3837585..3838243 Replicon chromosome
Accession NZ_CP048815
Organism Caulobacter rhizosphaerae strain KCTC 52515

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G3M57_RS17600 Protein ID WP_056756352.1
Coordinates 3837585..3837980 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G3M57_RS17605 Protein ID WP_056756354.1
Coordinates 3837977..3838243 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G3M57_RS17575 3832958..3833620 + 663 WP_056756340.1 phosphoribosylformylglycinamidine synthase subunit PurQ -
G3M57_RS17580 3833773..3834483 - 711 WP_163232010.1 hypothetical protein -
G3M57_RS17585 3834626..3836548 + 1923 WP_163232012.1 CocE/NonD family hydrolase -
G3M57_RS17590 3836749..3836907 - 159 WP_163232014.1 hypothetical protein -
G3M57_RS17595 3836992..3837588 - 597 WP_163232016.1 peptidylprolyl isomerase -
G3M57_RS17600 3837585..3837980 - 396 WP_056756352.1 type II toxin-antitoxin system VapC family toxin Toxin
G3M57_RS17605 3837977..3838243 - 267 WP_056756354.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
G3M57_RS17610 3838311..3840524 + 2214 WP_056756357.1 phosphoribosylformylglycinamidine synthase subunit PurL -
G3M57_RS17615 3840536..3840892 + 357 WP_163232018.1 hypothetical protein -
G3M57_RS17620 3840889..3841425 - 537 WP_163232020.1 helix-turn-helix transcriptional regulator -
G3M57_RS17625 3841549..3842358 + 810 WP_163232022.1 SDR family NAD(P)-dependent oxidoreductase -
G3M57_RS17630 3842621..3842827 + 207 WP_056756368.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(1-86)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14578.74 Da        Isoelectric Point: 8.3680

>T150052 WP_056756352.1 NZ_CP048815:c3837980-3837585 [Caulobacter rhizosphaerae]
MIVDTSALLAIALREPERDAFYVLLLRAKRRLMSAASYVEAAEVYMRRTSALTGIALLNRDLAQLRIEIVAVTAEQAYAA
AEARRVYGKSRHDADLNYGDSFSYALAKSLDEPLLFKGNDFIHTDVKRAAP

Download         Length: 396 bp

>T150052 NZ_CP064383:c4047011-4046736 [Escherichia coli O157:H7]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGC
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9764.86 Da        Isoelectric Point: 4.2052

>AT150052 WP_056756354.1 NZ_CP048815:c3838243-3837977 [Caulobacter rhizosphaerae]
MGISIKRAETEALARQVADATGESLTEAIHQALVEKVARLSEPYALSEAEEATKQAFFAELDARPILDPRDWREIEAELY
DEHGQPIG

Download         Length: 267 bp

>AT150052 NZ_CP064383:c4046739-4046380 [Escherichia coli O157:H7]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References