Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 1209561..1210261 Replicon chromosome
Accession NZ_CP048815
Organism Caulobacter rhizosphaerae strain KCTC 52515

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G3M57_RS05635 Protein ID WP_163229324.1
Coordinates 1209561..1209983 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G3M57_RS05640 Protein ID WP_056754148.1
Coordinates 1209983..1210261 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G3M57_RS05620 1206633..1207319 - 687 WP_163229318.1 GNAT family N-acetyltransferase -
G3M57_RS05625 1207612..1208226 - 615 WP_163229320.1 TetR/AcrR family transcriptional regulator -
G3M57_RS05630 1208299..1209564 + 1266 WP_208789679.1 MFS transporter -
G3M57_RS05635 1209561..1209983 - 423 WP_163229324.1 type II toxin-antitoxin system VapC family toxin Toxin
G3M57_RS05640 1209983..1210261 - 279 WP_056754148.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
G3M57_RS05645 1210351..1210560 - 210 WP_028041048.1 DUF3126 family protein -
G3M57_RS05650 1210612..1211565 - 954 WP_163229326.1 LysR family transcriptional regulator -
G3M57_RS05655 1211637..1211780 + 144 WP_163229328.1 hypothetical protein -
G3M57_RS05660 1211969..1214887 - 2919 WP_163229330.1 insulinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-51)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15448.70 Da        Isoelectric Point: 6.4746

>T150049 WP_163229324.1 NZ_CP048815:c1209983-1209561 [Caulobacter rhizosphaerae]
MFLLDTNVLSDATKLVPHPAVTRWLEAQPLSTLFVSVMSLAEASYGIERRPDGRKADGLRQWLGAVIVDFDGRLLPVDAE
VAMAQARIRRAAENARRTMSAIDAFIAATAEVHGLTLVTRNVRDFETWGGTVFNPWDKAP

Download         Length: 423 bp

>T150049 NZ_CP064383:3703503-3703967 [Escherichia coli O157:H7]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10311.58 Da        Isoelectric Point: 5.1771

>AT150049 WP_056754148.1 NZ_CP048815:c1210261-1209983 [Caulobacter rhizosphaerae]
MPDGTWSLADAKAKLSEVVERAKTQGPQHLTKNGKDAAVVLSAEEYRRLVEAGDGVPKRPPAWLDPRFRLLTDDEHAELF
TRDPDQGRVIEF

Download         Length: 279 bp

>AT150049 NZ_CP064383:3703168-3703503 [Escherichia coli O157:H7]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAGCAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATACAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References