Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 2331818..2332779 Replicon chromosome
Accession NZ_CP048814
Organism Rhodococcus triatomae strain DSM 44892

Toxin (Protein)


Gene name pezT Uniprot ID A0A1G8LI48
Locus tag G4H71_RS10945 Protein ID WP_072740315.1
Coordinates 2331818..2332399 (-) Length 194 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID A0A1G8LI07
Locus tag G4H71_RS10950 Protein ID WP_072740314.1
Coordinates 2332396..2332779 (-) Length 128 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G4H71_RS10925 2327880..2329154 + 1275 WP_072740317.1 ABC transporter substrate-binding protein -
G4H71_RS10930 2329241..2330302 + 1062 WP_083343151.1 sugar ABC transporter permease -
G4H71_RS10935 2330302..2331198 + 897 WP_083343150.1 carbohydrate ABC transporter permease -
G4H71_RS10940 2331204..2331392 + 189 WP_072740316.1 hypothetical protein -
G4H71_RS10945 2331818..2332399 - 582 WP_072740315.1 zeta toxin family protein Toxin
G4H71_RS10950 2332396..2332779 - 384 WP_072740314.1 hypothetical protein Antitoxin
G4H71_RS10955 2333076..2335124 + 2049 WP_083343165.1 penicillin-binding protein -
G4H71_RS10960 2335249..2336346 - 1098 WP_072740312.1 inositol-3-phosphate synthase -
G4H71_RS10965 2336339..2336896 - 558 WP_072740311.1 PadR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(3-136)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-64)


Sequences

Toxin        


Download         Length: 194 a.a.        Molecular weight: 21970.19 Da        Isoelectric Point: 10.8570

>T150046 WP_072740315.1 NZ_CP048814:c2332399-2331818 [Rhodococcus triatomae]
MTTPRLDLVVGCNGAGKSSLIREVLLPRLPGSLYVNADDIAQRRWPDDAENRSYDAARIAERTRDALIVAGKPFIAETVF
SHPSKLELVENAHRQGFRVVLHVVVVPEELAVHRVRLRRQSGGHAVPEQKIRARYQRVWPLAAEAITRCEQAYLYDNSRR
RMRRVARFVEGIEVTDHARPAWFPAALSRARHP

Download         Length: 582 bp

>T150046 NZ_CP064383:c3320420-3320085 [Escherichia coli O157:H7]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 128 a.a.        Molecular weight: 13742.01 Da        Isoelectric Point: 4.2945

>AT150046 WP_072740314.1 NZ_CP048814:c2332779-2332396 [Rhodococcus triatomae]
MTSADKVTRFSPDLWGDAVTAGVREQRSARQQLEHWARVGRAVSDRSSTGRRRIESALAGTLPSAQLTTDEAVVFDAEID
ASIEADLAEFDFVASRAQRGFTSVALDEQGELVEYGPDGSERALPGE

Download         Length: 384 bp

>AT150046 NZ_CP064383:c3320668-3320420 [Escherichia coli O157:H7]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1G8LI48

Antitoxin

Source ID Structure
AlphaFold DB A0A1G8LI07

References