Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-YefM
Location 848955..849470 Replicon chromosome
Accession NZ_CP048814
Organism Rhodococcus triatomae strain DSM 44892

Toxin (Protein)


Gene name relB Uniprot ID A0A1G7ZIM2
Locus tag G4H71_RS03990 Protein ID WP_072736704.1
Coordinates 848955..849209 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1G7ZIL0
Locus tag G4H71_RS03995 Protein ID WP_072736703.1
Coordinates 849210..849470 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G4H71_RS03965 844430..845392 - 963 WP_072736708.1 esterase family protein -
G4H71_RS03970 845601..847109 + 1509 WP_174561827.1 multidrug efflux MFS transporter -
G4H71_RS03975 847349..847660 - 312 WP_072736707.1 integration host factor -
G4H71_RS03980 847969..848274 - 306 WP_139183102.1 hypothetical protein -
G4H71_RS03985 848448..848777 - 330 WP_072736705.1 hypothetical protein -
G4H71_RS03990 848955..849209 - 255 WP_072736704.1 Txe/YoeB family addiction module toxin Toxin
G4H71_RS03995 849210..849470 - 261 WP_072736703.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
G4H71_RS04000 849621..849764 - 144 Protein_783 nucleotidyltransferase -
G4H71_RS04005 849769..850848 - 1080 WP_072736702.1 redox-regulated ATPase YchF -
G4H71_RS04010 850899..851519 - 621 WP_072736701.1 CD225/dispanin family protein -
G4H71_RS04015 851787..852917 + 1131 WP_083342836.1 AI-2E family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-65)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10008.36 Da        Isoelectric Point: 7.1631

>T150045 WP_072736704.1 NZ_CP048814:c849209-848955 [Rhodococcus triatomae]
VRLVWDESAWEDYKHWQTADRKILKRINTLIDACLREPFSGIGKPEQLKYGAQGSWSRRITDEQRLVYLVGDEDLVILQA
RYHY

Download         Length: 255 bp

>T150045 NZ_CP064383:c2218804-2218701 [Escherichia coli O157:H7]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9677.86 Da        Isoelectric Point: 5.1409

>AT150045 WP_072736703.1 NZ_CP048814:c849470-849210 [Rhodococcus triatomae]
MSISASEARKTLFPLIERVNADRDAVEIVSRKGNAVLMPADEYAAWQETAYLFRSPANARRLLDAYDRARGGKVEVHDLD
RVDQEA

Download         Length: 261 bp

>AT150045 NZ_CP064383:2218663-2218934 [Escherichia coli O157:H7]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1G7ZIM2

Antitoxin

Source ID Structure
AlphaFold DB A0A1G7ZIL0

References