150044

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 4163737..4164698 Replicon chromosome
Accession NZ_CP048813
Organism Rhodococcus triatomae strain DSM 44893

Toxin (Protein)


Gene name pezT Uniprot ID A0A1G8LI48
Locus tag G4H72_RS19435 Protein ID WP_072740315.1
Coordinates 4164117..4164698 (+) Length 194 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID A0A1G8LI07
Locus tag G4H72_RS19430 Protein ID WP_072740314.1
Coordinates 4163737..4164120 (+) Length 128 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G4H72_RS19415 4159620..4160177 + 558 WP_072740311.1 PadR family transcriptional regulator -
G4H72_RS19420 4160170..4161267 + 1098 WP_072740312.1 inositol-3-phosphate synthase -
G4H72_RS19425 4161392..4163440 - 2049 WP_083343165.1 penicillin-binding protein -
G4H72_RS19430 4163737..4164120 + 384 WP_072740314.1 hypothetical protein Antitoxin
G4H72_RS19435 4164117..4164698 + 582 WP_072740315.1 zeta toxin family protein Toxin
G4H72_RS19440 4165124..4165312 - 189 WP_072740316.1 hypothetical protein -
G4H72_RS19445 4165318..4166214 - 897 WP_083343150.1 carbohydrate ABC transporter permease -
G4H72_RS19450 4166214..4167275 - 1062 WP_083343151.1 sugar ABC transporter permease -
G4H72_RS19455 4167362..4168636 - 1275 WP_072740317.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(3-136)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-64)


Sequences

Toxin        


Download         Length: 194 a.a.        Molecular weight: 21970.19 Da        Isoelectric Point: 10.8570

>T150044 WP_072740315.1 NZ_CP048813:4164117-4164698 [Rhodococcus triatomae]
MTTPRLDLVVGCNGAGKSSLIREVLLPRLPGSLYVNADDIAQRRWPDDAENRSYDAARIAERTRDALIVAGKPFIAETVF
SHPSKLELVENAHRQGFRVVLHVVVVPEELAVHRVRLRRQSGGHAVPEQKIRARYQRVWPLAAEAITRCEQAYLYDNSRR
RMRRVARFVEGIEVTDHARPAWFPAALSRARHP

Download         Length: 582 bp

>T150044 NZ_CP064383:1942872-1943150 [Escherichia coli O157:H7]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 128 a.a.        Molecular weight: 13742.01 Da        Isoelectric Point: 4.2945

>AT150044 WP_072740314.1 NZ_CP048813:4163737-4164120 [Rhodococcus triatomae]
MTSADKVTRFSPDLWGDAVTAGVREQRSARQQLEHWARVGRAVSDRSSTGRRRIESALAGTLPSAQLTTDEAVVFDAEID
ASIEADLAEFDFVASRAQRGFTSVALDEQGELVEYGPDGSERALPGE

Download         Length: 384 bp

>AT150044 NZ_CP064383:1942679-1942870 [Escherichia coli O157:H7]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1G8LI48

Antitoxin

Source ID Structure
AlphaFold DB A0A1G8LI07

References