Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 1971155..1971690 Replicon chromosome
Accession NZ_CP048813
Organism Rhodococcus triatomae strain DSM 44893

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag G4H72_RS08885 Protein ID WP_072740057.1
Coordinates 1971155..1971484 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag G4H72_RS08890 Protein ID WP_072740058.1
Coordinates 1971481..1971690 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G4H72_RS08865 1967228..1967884 + 657 WP_072740053.1 hypothetical protein -
G4H72_RS08870 1967881..1968327 + 447 WP_072740054.1 hypothetical protein -
G4H72_RS08875 1968327..1969760 + 1434 WP_072740055.1 condensation protein -
G4H72_RS08880 1969794..1970642 - 849 WP_072740056.1 alpha/beta hydrolase -
G4H72_RS08885 1971155..1971484 - 330 WP_072740057.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
G4H72_RS08890 1971481..1971690 - 210 WP_072740058.1 DUF3018 family protein Antitoxin
G4H72_RS08895 1971936..1972952 - 1017 WP_083343102.1 NADP-dependent oxidoreductase -
G4H72_RS08900 1973030..1973464 + 435 WP_072740059.1 MarR family transcriptional regulator -
G4H72_RS08905 1973513..1974223 - 711 WP_072740060.1 hypothetical protein -
G4H72_RS08910 1974259..1975014 - 756 WP_083343120.1 DUF4111 domain-containing protein -
G4H72_RS08915 1975122..1975577 - 456 WP_139183266.1 DUF2628 domain-containing protein -
G4H72_RS08920 1975730..1976308 + 579 WP_083343121.1 nitroreductase family deazaflavin-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-104)

Antitoxin

Antitoxin MazE-like

(4-67)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11924.88 Da        Isoelectric Point: 5.1213

>T150042 WP_072740057.1 NZ_CP048813:c1971484-1971155 [Rhodococcus triatomae]
VIRGEVWTVTGDVYASKPRPAVIIQDDLFDATLSVVVAPMTSNLIEAPLMRIRIPAGGELSGLDRDSDVMVDKMTAVRRS
NVLTRVGRLTSEQLVEVERSLMAFLGLAR

Download         Length: 330 bp

>T150042 NZ_CP064383:c1410150-1410043 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7884.62 Da        Isoelectric Point: 4.7640

>AT150042 WP_072740058.1 NZ_CP048813:c1971690-1971481 [Rhodococcus triatomae]
VAVRDRVGDYRRRMRERGLRPLQVWVPDVRTATFAAEAHRQSALVAATDSHGDEQDFVDSIATSWDDEE

Download         Length: 210 bp

>AT150042 NZ_CP064383:1410198-1410257 [Escherichia coli O157:H7]
GTCTGGTTTCAAGATTAGCCCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References