Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-YefM
Location 872297..872812 Replicon chromosome
Accession NZ_CP048813
Organism Rhodococcus triatomae strain DSM 44893

Toxin (Protein)


Gene name relB Uniprot ID A0A1G7ZIM2
Locus tag G4H72_RS04055 Protein ID WP_072736704.1
Coordinates 872558..872812 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1G7ZIL0
Locus tag G4H72_RS04050 Protein ID WP_072736703.1
Coordinates 872297..872557 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G4H72_RS04030 868850..869980 - 1131 WP_083342836.1 AI-2E family transporter -
G4H72_RS04035 870248..870868 + 621 WP_072736701.1 CD225/dispanin family protein -
G4H72_RS04040 870919..871998 + 1080 WP_072736702.1 redox-regulated ATPase YchF -
G4H72_RS04045 872003..872146 + 144 Protein_796 nucleotidyltransferase -
G4H72_RS04050 872297..872557 + 261 WP_072736703.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
G4H72_RS04055 872558..872812 + 255 WP_072736704.1 Txe/YoeB family addiction module toxin Toxin
G4H72_RS04060 872990..873319 + 330 WP_072736705.1 hypothetical protein -
G4H72_RS04065 873493..873798 + 306 WP_139183102.1 hypothetical protein -
G4H72_RS04070 874107..874418 + 312 WP_072736707.1 integration host factor -
G4H72_RS04075 874658..876167 - 1510 Protein_802 multidrug efflux MFS transporter -
G4H72_RS04080 876375..877337 + 963 WP_072736708.1 esterase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-65)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10008.36 Da        Isoelectric Point: 7.1631

>T150041 WP_072736704.1 NZ_CP048813:872558-872812 [Rhodococcus triatomae]
VRLVWDESAWEDYKHWQTADRKILKRINTLIDACLREPFSGIGKPEQLKYGAQGSWSRRITDEQRLVYLVGDEDLVILQA
RYHY

Download         Length: 255 bp

>T150041 NZ_CP064383:c1409614-1409507 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9677.86 Da        Isoelectric Point: 5.1409

>AT150041 WP_072736703.1 NZ_CP048813:872297-872557 [Rhodococcus triatomae]
MSISASEARKTLFPLIERVNADRDAVEIVSRKGNAVLMPADEYAAWQETAYLFRSPANARRLLDAYDRARGGKVEVHDLD
RVDQEA

Download         Length: 261 bp

>AT150041 NZ_CP064383:1409667-1409728 [Escherichia coli O157:H7]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1G7ZIM2

Antitoxin

Source ID Structure
AlphaFold DB A0A1G7ZIL0

References