Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2026206..2026882 Replicon chromosome
Accession NZ_CP048812
Organism Halomonas socia strain CKY01

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G3568_RS09665 Protein ID WP_163501982.1
Coordinates 2026457..2026882 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G3568_RS09660 Protein ID WP_163501981.1
Coordinates 2026206..2026460 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G3568_RS09630 2022363..2022677 + 315 WP_163501976.1 hypothetical protein -
G3568_RS09635 2022757..2023725 + 969 WP_163501977.1 DUF932 domain-containing protein -
G3568_RS09640 2023803..2023988 + 186 WP_163501978.1 hypothetical protein -
G3568_RS09645 2023999..2024760 + 762 WP_163501979.1 ERF family protein -
G3568_RS09650 2024819..2025430 + 612 WP_163501345.1 YqaJ viral recombinase family protein -
G3568_RS09655 2025442..2025939 + 498 WP_163501980.1 DNA repair protein RadC -
G3568_RS09660 2026206..2026460 + 255 WP_163501981.1 Arc family DNA-binding protein Antitoxin
G3568_RS09665 2026457..2026882 + 426 WP_163501982.1 type II toxin-antitoxin system VapC family toxin Toxin
G3568_RS09670 2026955..2029701 + 2747 Protein_1895 class I SAM-dependent DNA methyltransferase -
G3568_RS09675 2029698..2030489 + 792 WP_163501983.1 hypothetical protein -
G3568_RS09680 2030486..2031496 + 1011 WP_163501984.1 virulence RhuM family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1989256..2065189 75933


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15002.34 Da        Isoelectric Point: 5.1970

>T150038 WP_163501982.1 NZ_CP048812:2026457-2026882 [Halomonas socia]
MILLDTNVISEPLRREPEARVIEWIDTQPLETLFLSAITVAELRAGIALLSAGKRRAGLQENLEKRVLPLFAGRVLSFDL
PCTQAYAELIARARKAGLAMAAADGYLAAIAAANGLSVATRDTSPFEAAGTAVINPWNASA

Download         Length: 426 bp

>T150038 NZ_CP064383:c128368-128150 [Escherichia coli O157:H7]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9233.52 Da        Isoelectric Point: 5.6227

>AT150038 WP_163501981.1 NZ_CP048812:2026206-2026460 [Halomonas socia]
MAMLTVRNLPDEVHRALRVRAALHGHSMEAEVREILEAAVAPEGRVKLGSLLADIGRQAQLTDEEFAAFGDVRDKTPARP
ANFE

Download         Length: 255 bp

>AT150038 NZ_CP064383:c128768-128394 [Escherichia coli O157:H7]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACTCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References