Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4791780..4792296 Replicon chromosome
Accession NZ_CP048800
Organism Klebsiella pneumoniae strain EGKP4

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag G4I41_RS23640 Protein ID WP_002886902.1
Coordinates 4791780..4792064 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag G4I41_RS23645 Protein ID WP_002886901.1
Coordinates 4792054..4792296 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G4I41_RS23615 (4787196) 4787196..4787459 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
G4I41_RS23620 (4787589) 4787589..4787762 + 174 WP_032414892.1 hypothetical protein -
G4I41_RS23625 (4787765) 4787765..4788508 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
G4I41_RS23630 (4788865) 4788865..4791003 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
G4I41_RS23635 (4791312) 4791312..4791776 + 465 WP_023302390.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
G4I41_RS23640 (4791780) 4791780..4792064 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G4I41_RS23645 (4792054) 4792054..4792296 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
G4I41_RS23650 (4792374) 4792374..4794284 - 1911 WP_009486549.1 PRD domain-containing protein -
G4I41_RS23655 (4794307) 4794307..4795461 - 1155 WP_023302389.1 lactonase family protein -
G4I41_RS23660 (4795528) 4795528..4796268 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T150022 WP_002886902.1 NZ_CP048800:c4792064-4791780 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T150022 NZ_CP064376:1383110-1383400 [Shigella sonnei]
ATGTTACCCGTTTTATGGCTACCATCTGCTCGTGATGATTTGCGCCAGATCGTAGCCTACATAGCTAAAGAAAATCCCGC
GGCAGCACGCAGAATGAAAATTCGAATTGAAACATCCGTTTTGCCGCTCACAGAGCATCCTTACCTGTATCCTCCAAGCG
AGCGAGTTCTTGGTCTTCGTGAAATTGTAACTCATCCTAACTACATCATCCTTTACCGAGTAACAGCATCAAGCATAGAA
GTAGTAAATATTGTGCATTCTCGAAGACAGTATCCAGGCAAAAACAGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT150022 WP_002886901.1 NZ_CP048800:c4792296-4792054 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT150022 NZ_CP064376:1382916-1383110 [Shigella sonnei]
ATGAGTACAGTCCTTTCCCCAATGGTTTCAGAATTTGAGACAGTTGAGCAAGAAAATAGTTACAACGAATGGCTGCGGGC
CAAAGTAGCAGCAAGCCTCGCGGATCCCCGCCCGGCGATTCCGCATGATGAGGTAATGGCGGAAATGGAACAAATTATTG
CCCAAATTGCTGCTGCAACTCACAGAGGTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References