Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 819255..819912 Replicon chromosome
Accession NZ_CP048800
Organism Klebsiella pneumoniae strain EGKP4

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag G4I41_RS04145 Protein ID WP_002916310.1
Coordinates 819502..819912 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag G4I41_RS04140 Protein ID WP_002916312.1
Coordinates 819255..819521 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G4I41_RS04115 (814411) 814411..815844 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
G4I41_RS04120 (815963) 815963..816691 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
G4I41_RS04125 (816741) 816741..817052 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
G4I41_RS04130 (817216) 817216..817875 + 660 WP_002916317.1 hemolysin III family protein -
G4I41_RS04135 (818026) 818026..819009 - 984 WP_004185555.1 tRNA-modifying protein YgfZ -
G4I41_RS04140 (819255) 819255..819521 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
G4I41_RS04145 (819502) 819502..819912 + 411 WP_002916310.1 protein YgfX Toxin
G4I41_RS04150 (819919) 819919..820440 - 522 WP_004144730.1 flavodoxin FldB -
G4I41_RS04155 (820541) 820541..821437 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
G4I41_RS04160 (821460) 821460..822173 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
G4I41_RS04165 (822179) 822179..823912 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T150010 WP_002916310.1 NZ_CP048800:819502-819912 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T150010 NZ_CP064374:695441-695584 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTAAAAGAAAACAATAAAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT150010 WP_002916312.1 NZ_CP048800:819255-819521 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT150010 NZ_CP064374:c695344-695143 [Enterococcus faecalis]
GTTTTTTTAGGTAATTGTGCTATAATAGCAATGAAAAGAGAGATATGCGCCAACATACCTCTCTGATGTAGAGCCGTTTA
AGACGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCA
ATTTCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References