Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 4274424..4276153 Replicon chromosome
Accession NZ_CP048796
Organism Providencia vermicola strain P8538

Toxin (Protein)


Gene name pmenT Uniprot ID -
Locus tag G3341_RS19470 Protein ID WP_154623506.1
Coordinates 4274424..4275068 (+) Length 215 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID -
Locus tag G3341_RS19475 Protein ID WP_154623505.1
Coordinates 4275080..4276153 (+) Length 358 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G3341_RS19455 4272010..4272840 + 831 WP_163863435.1 formate dehydrogenase accessory sulfurtransferase FdhD -
G3341_RS19460 4272844..4273623 - 780 WP_154624784.1 transferase -
G3341_RS19465 4273855..4274424 + 570 WP_163863437.1 DUF4433 domain-containing protein -
G3341_RS19470 4274424..4275068 + 645 WP_154623506.1 DUF4433 domain-containing protein Toxin
G3341_RS19475 4275080..4276153 + 1074 WP_154623505.1 macro domain-containing protein Antitoxin
G3341_RS19480 4276255..4277619 - 1365 WP_163863439.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
G3341_RS19485 4277719..4279368 - 1650 WP_154623503.1 membrane protein insertase YidC -
G3341_RS19490 4279371..4279631 - 261 WP_014657163.1 membrane protein insertion efficiency factor YidD -
G3341_RS19495 4279595..4279954 - 360 WP_163863441.1 ribonuclease P protein component -
G3341_RS19500 4279976..4280119 - 144 WP_004906236.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(14-214)

Antitoxin

Macro domain

(18-129)


Sequences

Toxin        


Download         Length: 215 a.a.        Molecular weight: 25047.66 Da        Isoelectric Point: 6.9106

>T150005 WP_154623506.1 NZ_CP048796:4274424-4275068 [Providencia vermicola]
MAYMNLNPEKALIWRITHRQNIPWLFANGLYAGNSEHYSPNWVTIGNTDLINRRNQRHVPIQPNGVLNDYVPFYFTPFSP
MMYNIYTGRGGVRKVPNDDIIILVSSMYKIAALKIPFVFTDRHAYPVTSQFYNQLTDLAEIDWALLQQRNFHRDPDDPEK
VERYQAEALIYKHVPMEALLGAVCYTKETQLELQAKASQLEIHLDIHCIPNWYF

Download         Length: 645 bp

>T150005 NZ_CP064374:c621119-620976 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTGTTGTCAGCATATGAGACAATTCAGACGATCCTAGGTTTTGG
TATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 358 a.a.        Molecular weight: 40807.28 Da        Isoelectric Point: 7.8198

>AT150005 WP_154623505.1 NZ_CP048796:4275080-4276153 [Providencia vermicola]
MIEFTQGNLLEADVEALVNTVNTVGVMGKGIALMFKERFPANMAAYAKACKTHEVQTGKMFVTETGELMGPRWIVNFPTK
QHWRAKSQIQWIIDGLLDLRNFIEENHVKSIAIPPLGAGNGGLNWDDVKPHIVEILGDIQNVKIIVYEPIAKYQNVAKPK
GVEKLTPARALIAELIRRYWVMGMDCSLLEIQKLAWFLERTIEAEGLRNPLNLRFEARNYGPYADKLRHLLNGLDGSYLK
SEKRISDCSPLDVIWFNDDKRATIELYLKTEAKDYLSALEKTTKLIDGFESPFGIELLSTVDWLLYKKQSSPNIESLLEG
MRQWPAGDRWAQRKLRLFDSNKLELALNHLKQIPFYS

Download         Length: 1074 bp

>AT150005 NZ_CP064374:620857-621043 [Enterococcus faecalis]
TGTGCTAGAATGTAGATGAAAAGAGAGATATGCGTCAACATACCTCTCTAGTGTAGAGCCGTTTGAGACGGTGACCGATT
GTATTATTTAAAAATAACCGTACTGGTCAAAGTAGATGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGTG
CAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References