Detailed information of TA system TA150003

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 1460154..1460811
• Replicon: chromosome
• Accession: NZ_CP048796
• Organism: Providencia vermicola strain P8538

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: G3341_RS06255
• Protein ID: WP_163860914.1
• Coordinates: 1460401..1460811 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: G3341_RS06250
• Protein ID: WP_154624313.1
• Coordinates: 1460154..1460420 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G3341_RS06235	1455306..1458182	+	2877	WP_163860913.1	aminomethyl-transferring glycine dehydrogenase	-
G3341_RS06240	1458279..1458899	-	621	WP_154624315.1	HD domain-containing protein	-
G3341_RS06245	1458911..1459900	-	990	WP_154624314.1	tRNA-modifying protein YgfZ	-
G3341_RS06250	1460154..1460420	+	267	WP_154624313.1	FAD assembly factor SdhE	Antitoxin
G3341_RS06255	1460401..1460811	+	411	WP_163860914.1	hypothetical protein	Toxin
G3341_RS06260	1460856..1461374	-	519	WP_154624312.1	flavodoxin FldB	-
G3341_RS06265	1461459..1462382	+	924	WP_154624329.1	site-specific tyrosine recombinase XerD	-
G3341_RS06270	1462402..1463103	+	702	WP_154624311.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
G3341_RS06275	1463113..1464846	+	1734	WP_163860916.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-133)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15375.24 Da
• Isoelectric Point: 10.8779

>T150003 WP_163860914.1 NZ_CP048796:1460401-1460811 [Providencia vermicola]
VVLWKSNLSISWKTQLFSTCAHGLVGFILLVAPWAPGNSMVWLPLLAIVIASWAKSQKSISKIKGTAVLVNGNKVQWKKN
EWNIIKQPWCSRVGILLTLSALQGKQQKIRLWIAKDALSEESWRNLNQLLLQYPDI

Nucleotide

• Length: 411 bp

>T150003 NZ_CP064374:c549574-549473 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACAATAAAAAATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10578.07 Da
• Isoelectric Point: 4.7132

>AT150003 WP_154624313.1 NZ_CP048796:1460154-1460420 [Providencia vermicola]
MDIENKARIHWACRRGMRELDISIMPFFEYEYDSLSDKDKQTFVRLLECADPDLFNWLMNHGRPDDEELFGMVKLIQERN
KNRGPVEI

Nucleotide

• Length: 267 bp

>AT150003 NZ_CP064374:549354-549528 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTT
TTGAATCTTAACCGTTCGGCCTACGAAGCTTGTGAACGGTTATTTTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAA
TCAGTAGTGCAACAA