Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 831045..831619 Replicon chromosome
Accession NZ_CP048792
Organism Pasteurella multocida strain VP161

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag PmVP161_RS03785 Protein ID WP_061406134.1
Coordinates 831335..831619 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag PmVP161_RS03780 Protein ID WP_135938169.1
Coordinates 831045..831338 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PmVP161_RS03760 826204..827295 - 1092 WP_005751571.1 L-ascorbate 6-phosphate lactonase -
PmVP161_RS03765 827645..829435 + 1791 WP_061406132.1 PTS ascorbate-specific subunit IIBC -
PmVP161_RS03770 829480..829947 + 468 WP_064661066.1 PTS sugar transporter subunit IIA -
PmVP161_RS03775 829965..830642 + 678 WP_005726756.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
PmVP161_RS03780 831045..831338 - 294 WP_135938169.1 putative addiction module antidote protein Antitoxin
PmVP161_RS03785 831335..831619 - 285 WP_061406134.1 hypothetical protein Toxin
PmVP161_RS03795 832898..833257 - 360 WP_095261631.1 DUF3418 domain-containing protein -
PmVP161_RS03800 833317..833952 + 636 Protein_716 NERD domain-containing protein -
PmVP161_RS03805 834288..835826 + 1539 WP_061406430.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-87)

Antitoxin

Uncharacterized protein HI1420

(5-92)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10667.40 Da        Isoelectric Point: 10.2297

>T149998 WP_061406134.1 NZ_CP048792:c831619-831335 [Pasteurella multocida]
VGRLKEVKILSAKSAVLARINKAMNGNFGDHKSIGNGLYEMRIIKGSGYRVYYGQYREVTYLLICGGDKSTQKSDIVKAR
ELWKEIKQQEEVKV

Download         Length: 285 bp

>T149998 NZ_CP064370:c97375-96959 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCATTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCAGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAAACCTCCCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCAGTGGACGCCACGACGGGCATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCTATTGC
CGGCCACCCCATCGCGGCCGGCGCCGTCCTGGTGACGAACAATGTGCGGGAGTTTGCGCGGGTCCCGGGTCTGGTGCTGG
AAGACTGGGTGGAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10948.83 Da        Isoelectric Point: 7.2766

>AT149998 WP_135938169.1 NZ_CP048792:c831338-831045 [Pasteurella multocida]
MSKKKIKLKLFDIAEHLDSEEMIAAYLSEVLETCDTNEFISALSDVVRAKGMTELAAKTGLRRESLYKTLSYGSEPRFDT
IMKIMHSLGIKLVPTHI

Download         Length: 294 bp

>AT149998 NZ_CP064370:c97602-97372 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGAGGGGGTGAG
CGAGCAGGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAACTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGAATGTGGTCAGCGATGAAGGACGCTTTAAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References