Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-MqsA
Location 3726764..3727463 Replicon chromosome
Accession NZ_CP048787
Organism Proteus mirabilis strain CC15031

Toxin (Protein)


Gene name relE Uniprot ID B4EZ96
Locus tag G4D35_RS17405 Protein ID WP_004249093.1
Coordinates 3726764..3727150 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B4EZ97
Locus tag G4D35_RS17410 Protein ID WP_004246828.1
Coordinates 3727143..3727463 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G4D35_RS17390 3722783..3723364 - 582 WP_012368524.1 DNA-3-methyladenine glycosylase I -
G4D35_RS17395 3723615..3724520 + 906 WP_004246832.1 glycine--tRNA ligase subunit alpha -
G4D35_RS17400 3724530..3726602 + 2073 WP_017628659.1 glycine--tRNA ligase subunit beta -
G4D35_RS17405 3726764..3727150 + 387 WP_004249093.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G4D35_RS17410 3727143..3727463 + 321 WP_004246828.1 helix-turn-helix domain-containing protein Antitoxin
G4D35_RS17415 3727512..3727946 - 435 WP_163801802.1 hypothetical protein -
G4D35_RS17420 3727939..3728823 - 885 WP_004249091.1 endonuclease/exonuclease/phosphatase family protein -
G4D35_RS17425 3729038..3730324 - 1287 WP_087741020.1 DUF3748 domain-containing protein -
G4D35_RS17430 3730461..3731078 + 618 WP_004246822.1 trimeric intracellular cation channel family protein -
G4D35_RS17435 3731379..3732002 + 624 WP_004246821.1 guanylate kinase -
G4D35_RS17440 3732057..3732332 + 276 WP_004246820.1 DNA-directed RNA polymerase subunit omega -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-125)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-95)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14294.64 Da        Isoelectric Point: 10.0642

>T149995 WP_004249093.1 NZ_CP048787:3726764-3727150 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Download         Length: 387 bp

>T149995 NZ_CP064368:5231053-5231155 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12126.21 Da        Isoelectric Point: 10.4411

>AT149995 WP_004246828.1 NZ_CP048787:3727143-3727463 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Download         Length: 321 bp

>AT149995 NZ_CP064368:c5231162-5231017 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4EZ96

Antitoxin

Source ID Structure
AlphaFold DB B4EZ97

References