Detailed information of TA system TA149990

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelE-RHH
• Location: 4927625..4928190
• Replicon: chromosome
• Accession: NZ_CP048784
• Organism: Serratia liquefaciens strain S1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: F0336_RS23290
• Protein ID: WP_020837304.1
• Coordinates: 4927912..4928190 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A380ARC2
• Locus tag: F0336_RS23285
• Protein ID: WP_020837302.1
• Coordinates: 4927625..4927894 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F0336_RS23270	4923838..4925055	-	1218	WP_149573905.1	aspartate aminotransferase family protein	-
F0336_RS23275	4925187..4925762	-	576	WP_149573906.1	aminodeoxychorismate synthase component II	-
F0336_RS23280	4925873..4927399	-	1527	WP_048760525.1	DUF853 family protein	-
F0336_RS23285	4927625..4927894	+	270	WP_020837302.1	hypothetical protein	Antitoxin
F0336_RS23290	4927912..4928190	+	279	WP_020837304.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
F0336_RS23295	4928191..4928916	-	726	WP_149573907.1	two-component system response regulator BtsR	-
F0336_RS23300	4928916..4930601	-	1686	WP_046372487.1	sensor histidine kinase	-
F0336_RS23305	4930763..4931332	-	570	WP_020837308.1	peptidylprolyl isomerase A	-
F0336_RS23310	4931690..4932028	+	339	WP_149573940.1	PTS lactose/cellobiose transporter subunit IIA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-89)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10374.00 Da
• Isoelectric Point: 9.8344

>T149990 WP_020837304.1 NZ_CP048784:4927912-4928190 [Serratia liquefaciens]
VKLKWTDPTIADRMAIYDYLASKNPIAAAEIDALISAAASQLSRNPSSGKVGRVSGTREWVIHHFYLLIYEVKNDLLIIL
AVVHSRRQWPKD

Nucleotide

• Length: 279 bp

>T149990 NZ_CP064368:c2615256-2614972 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10373.64 Da
• Isoelectric Point: 5.2281

>AT149990 WP_020837302.1 NZ_CP048784:4927625-4927894 [Serratia liquefaciens]
MSESTVVIRVDDELKIAFASAAKAADRTASQLLRDFMRDFVSRQSQQKEYEQWLQEKVDLSRKALQEGRVVDNEDVEAYF
AERRAKSMR

Nucleotide

• Length: 270 bp

>AT149990 NZ_CP064368:c2615488-2615246 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A380ARC2