Detailed information of TA system TA149989

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4319003..4319672
• Replicon: chromosome
• Accession: NZ_CP048784
• Organism: Serratia liquefaciens strain S1

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: F0336_RS20425
• Protein ID: WP_020828475.1
• Coordinates: 4319003..4319425 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A7W4F6J9
• Locus tag: F0336_RS20430
• Protein ID: WP_020828476.1
• Coordinates: 4319406..4319672 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F0336_RS20405	4314889..4315407	+	519	WP_020828471.1	flavodoxin FldB	-
F0336_RS20410	4315444..4316808	-	1365	WP_149573840.1	cell envelope integrity protein CreD	-
F0336_RS20415	4316893..4318311	-	1419	WP_149573839.1	two-component system sensor histidine kinase CreC	-
F0336_RS20420	4318308..4319003	-	696	WP_129984121.1	two-component system response regulator CreB	-
F0336_RS20425	4319003..4319425	-	423	WP_020828475.1	protein YgfX	Toxin
F0336_RS20430	4319406..4319672	-	267	WP_020828476.1	FAD assembly factor SdhE	Antitoxin
F0336_RS20435	4319995..4320981	+	987	WP_020828477.1	tRNA-modifying protein YgfZ	-
F0336_RS20440	4321039..4321536	-	498	WP_020828478.1	DUF2165 domain-containing protein	-
F0336_RS20445	4321700..4322374	-	675	WP_020828479.1	hemolysin III family protein	-
F0336_RS20450	4322558..4323166	+	609	WP_048760837.1	HD domain-containing protein	-
F0336_RS20455	4323207..4324532	-	1326	WP_046372712.1	MHS family MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16577.54 Da
• Isoelectric Point: 10.6957

>T149989 WP_020828475.1 NZ_CP048784:c4319425-4319003 [Serratia liquefaciens]
VAQWRCDVRISWRTQLLSLLTHGVLILLILISPWPEGYGPIWLVLLTLVVFECIRSQKRIASRQGELRLLENQRVGWQGQ
EWQLVKQPWMLRFGILLTLQPMQGKKRRRLWLASDSMAKAEWRHLRQQLLYPPASDDEEP

Nucleotide

• Length: 423 bp

>T149989 NZ_CP064368:c2535711-2535370 [Klebsiella pneumoniae]
ATGCAAACTCTACCTGCAACAACTCCGCAGGCGGTGACGCTATGTCTGTCGCCCGTGGCAGTATGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAGGGGATTC
AACTGGCAAGAACAGTCCCCATATCTGCGGGCGGTCGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTAAAAAGAAA
TCGTATTAGCGCGGCACGGTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10500.99 Da
• Isoelectric Point: 5.0990

>AT149989 WP_020828476.1 NZ_CP048784:c4319672-4319406 [Serratia liquefaciens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDRLNDTDKALFIRLLESDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT149989 NZ_CP064368:c2536073-2535732 [Klebsiella pneumoniae]
ATGAAATCTACTGACTCAGAGAACGATTCATTTCTCAAGTGGGGTCTGAATCGTAATGTGACACCTTGCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGGCTGCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTCAGCGAAGCAGAATGTC
TTAAGCTGGATGTGGCATTCCCACATTTTATCAGCCAGATGGAGTCGATGTTGACTACTGGTGAAATGAATCCTCGCCAT
GCCCACTGTGTCACCCTGTACCACAATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTACGGCTACGTATACATCGC
CGTTTACCCCACTCAACGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A7W4F6J9