Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3890929..3891581 Replicon chromosome
Accession NZ_CP048784
Organism Serratia liquefaciens strain S1

Toxin (Protein)


Gene name vapC Uniprot ID A0A379YFT9
Locus tag F0336_RS18425 Protein ID WP_020828096.1
Coordinates 3890929..3891315 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A379YGI8
Locus tag F0336_RS18430 Protein ID WP_020828097.1
Coordinates 3891318..3891581 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F0336_RS18410 3887394..3888824 + 1431 WP_020828093.1 MFS transporter -
F0336_RS18415 3888824..3890206 + 1383 WP_046372938.1 two-component system sensor histidine kinase BaeS -
F0336_RS18420 3890206..3890922 + 717 WP_020828095.1 two-component system response regulator BaeR -
F0336_RS18425 3890929..3891315 - 387 WP_020828096.1 type II toxin-antitoxin system VapC family toxin Toxin
F0336_RS18430 3891318..3891581 - 264 WP_020828097.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
F0336_RS18435 3891933..3892271 + 339 WP_020828098.1 YegP family protein -
F0336_RS18440 3892449..3893801 + 1353 WP_041414820.1 tRNA 5-hydroxyuridine modification protein YegQ -
F0336_RS18445 3894275..3895192 + 918 WP_149573715.1 lipid kinase YegS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14093.28 Da        Isoelectric Point: 7.8799

>T149987 WP_020828096.1 NZ_CP048784:c3891315-3890929 [Serratia liquefaciens]
MYMFDTNTVSQLFRRHPRLLSLMEKIPPSAVCISSITQAELLYGVAKRQNLALKATVAAFLDSVTVYAWDSEAAHCYGTL
RAEMTQKGRVMGALDQLIAAHAQSRGATIVTNDRAFAMVPGLTVEDWT

Download         Length: 387 bp

>T149987 NZ_CP064368:1868188-1868406 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGTCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10091.38 Da        Isoelectric Point: 5.8701

>AT149987 WP_020828097.1 NZ_CP048784:c3891581-3891318 [Serratia liquefaciens]
MERVAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLQMIEKTQVPHDFLAADERQQGSATR
DPFAGEE

Download         Length: 264 bp

>AT149987 NZ_CP064368:1867787-1868161 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A379YFT9

Antitoxin

Source ID Structure
AlphaFold DB A0A379YGI8

References