Detailed information of TA system TA149986

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3204415..3205040
• Replicon: chromosome
• Accession: NZ_CP048784
• Organism: Serratia liquefaciens strain S1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A515CU05
• Locus tag: F0336_RS15245
• Protein ID: WP_048760244.1
• Coordinates: 3204415..3204597 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: F0336_RS15250
• Protein ID: WP_046373264.1
• Coordinates: 3204627..3205040 (+)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F0336_RS15240	3200277..3204248	+	3972	WP_041414691.1	trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase	-
F0336_RS15245	3204415..3204597	+	183	WP_048760244.1	type II toxin-antitoxin system HicA family toxin	Toxin
F0336_RS15250	3204627..3205040	+	414	WP_046373264.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
F0336_RS15255	3205072..3205824	-	753	WP_046373263.1	L-cystine ABC transporter ATP-binding protein YecC	-
F0336_RS15260	3205828..3206490	-	663	WP_020827487.1	cystine ABC transporter permease	-
F0336_RS15265	3206490..3207290	-	801	WP_046373262.1	cystine ABC transporter substrate-binding protein	-
F0336_RS15270	3207405..3208397	-	993	WP_129940776.1	D-cysteine desulfhydrase	-
F0336_RS15275	3208525..3209034	-	510	WP_041414695.1	flagella biosynthesis regulatory protein FliZ	-
F0336_RS15280	3209093..3209815	-	723	WP_020827491.1	RNA polymerase sigma factor FliA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6768.95 Da
• Isoelectric Point: 10.7801

>T149986 WP_048760244.1 NZ_CP048784:3204415-3204597 [Serratia liquefaciens]
VKSSELIGLLEQEGWVLTRIKGSHHQFKHPNSRLVITVPHPRKDLKAGTLRQIMKDAGLC

Nucleotide

• Length: 183 bp

>T149986 NZ_CP064368:c554271-552949 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCTGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTTACCGCCTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCGGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCACTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCGCCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15079.73 Da
• Isoelectric Point: 4.8288

>AT149986 WP_046373264.1 NZ_CP048784:3204627-3205040 [Serratia liquefaciens]
MFYPAYVHSEPDGSASGFFPDVPGCYFAGDTLDRAFDDARSALDAHFEFLSEDNQPIPGPQAVTFHLAQNNDSLNGGQWL
LVNINMDKFDGRAERINITLPHRLLNRIDSLVQQHPGYGSRSAFLAAAARNELLKAG

Nucleotide

• Length: 414 bp

>AT149986 NZ_CP064368:c554537-554271 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Structures

Toxin

• AlphaFold DB: A0A515CU05