Detailed information of TA system TA149976

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 451088..451674
• Replicon: chromosome
• Accession: NZ_CP048784
• Organism: Serratia liquefaciens strain S1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: F0336_RS02125
• Protein ID: WP_048762831.1
• Coordinates: 451384..451674 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7W4F292
• Locus tag: F0336_RS02120
• Protein ID: WP_020824985.1
• Coordinates: 451088..451375 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F0336_RS02095	446824..447909	-	1086	WP_115060304.1	carbon-phosphorus lyase complex subunit PhnI	-
F0336_RS02100	447909..448490	-	582	WP_149573639.1	phosphonate C-P lyase system protein PhnH	-
F0336_RS02105	448493..448936	-	444	WP_046374634.1	phosphonate C-P lyase system protein PhnG	-
F0336_RS02110	448937..449662	-	726	WP_172958979.1	phosphonate metabolism transcriptional regulator PhnF	-
F0336_RS02115	449925..450983	+	1059	WP_020824984.1	permease	-
F0336_RS02120	451088..451375	+	288	WP_020824985.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
F0336_RS02125	451384..451674	+	291	WP_048762831.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
F0336_RS02130	451671..452135	-	465	WP_116691389.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
F0336_RS02135	452309..454447	-	2139	WP_149573638.1	anaerobic ribonucleoside-triphosphate reductase	-
F0336_RS02140	454731..455639	-	909	WP_149573637.1	LysR family transcriptional regulator	-
F0336_RS02145	455744..456268	+	525	WP_020824990.1	NAD(P)H-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-44)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11329.97 Da
• Isoelectric Point: 4.5865

>T149976 WP_048762831.1 NZ_CP048784:451384-451674 [Serratia liquefaciens]
MRVEWDEEALRDRERIFDFLYPFNPQAAEQADAEIDKAVKRLLDYPELGKIWYRQARKLLVSQASLLVLYVVVDDVIKVL
AVAHQREKFPDPDIEN

Nucleotide

• Length: 291 bp

>T149976 NZ_CP064363:3109392-3109676 [Salmonella enterica subsp. arizonae]
ATGACCTATGAGCTGGAGTTTGATCCACGCGCGCTAAAAGAGTGGCAAAAGCTGGGTGAAACGGTAAAAAAACAGTTCCG
CAAGAAACTTGTCGACGTGTTGTCAAATCCGCGGGTTGAGTCTGCGCGGCTGCGTGAACTGCCAGATTGCTACAAAATCA
AGCTGAAGACCTCAGGCTATCGTTTAGTGTATCAGGTGCAGGACGACGTGGTATTGGTGGTGGTGATTGCTATCGGCAAG
AGAGAGAAATCGGCCGTTTATCGCCAGGCAGACAAACGGCTTTAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 11043.40 Da
• Isoelectric Point: 6.4766

>AT149976 WP_020824985.1 NZ_CP048784:451088-451375 [Serratia liquefaciens]
MESRIQFRIEDETKRLAQKAAEAKGITLSEACRRLAEQMADEQRATEQHENWLKEKVDAAFARLHEGSAVYLDQQQVDES
MDAFKAKVRAKYDRK

Nucleotide

• Length: 288 bp

>AT149976 NZ_CP064363:3109160-3109402 [Salmonella enterica subsp. arizonae]
ATGGCCACACTTAACGTCCGTTTGGATGACAAACTCAAAAACGAGGCTTATGCCGTGCTGGAAAAACTCAATATTACCCC
CACAGAAGCTGTCCGGCTGTTGTTTCAATATGTGGCGGAAAACGGGCGTATGCCTGTTAAAACCGTTACGATTAGCGACA
GCGAAGACGCATTGCTACAGACAGTCCGGGAACGACTGGCTAACCCACAGAAAGGAATCAGAGTTAGTCTGGATGACCTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A7W4F292