Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4774925..4775441 Replicon chromosome
Accession NZ_CP048778
Organism Klebsiella pneumoniae strain EGKP7

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag G4D19_RS23490 Protein ID WP_002886902.1
Coordinates 4774925..4775209 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag G4D19_RS23495 Protein ID WP_002886901.1
Coordinates 4775199..4775441 (-) Length 81 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G4D19_RS23465 (4770341) 4770341..4770604 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
G4D19_RS23470 (4770734) 4770734..4770907 + 174 WP_032414892.1 hypothetical protein -
G4D19_RS23475 (4770910) 4770910..4771653 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
G4D19_RS23480 (4772010) 4772010..4774148 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
G4D19_RS23485 (4774457) 4774457..4774921 + 465 WP_023302390.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
G4D19_RS23490 (4774925) 4774925..4775209 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G4D19_RS23495 (4775199) 4775199..4775441 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
G4D19_RS23500 (4775519) 4775519..4777429 - 1911 WP_009486549.1 PRD domain-containing protein -
G4D19_RS23505 (4777452) 4777452..4778606 - 1155 WP_023302389.1 lactonase family protein -
G4D19_RS23510 (4778673) 4778673..4779413 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T149969 WP_002886902.1 NZ_CP048778:c4775209-4774925 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T149969 NZ_CP064363:231023-231406 [Salmonella enterica subsp. arizonae]
ATGATTTGGGTCAGCGCGCAGGAAGTCATTGCCTTCCACGATCGTATTTTGCAACGCTTTCCCGGAGTGGTTGGCCTGTC
TGACCCTGGCAGAGCACAGGCATTGATTTATCGGGTGCAGAATCGTGTTCACTACGAAGGCGTTACTGACCTGTTTGAAC
TGGCGGCTACCTACTGGGTCGCTATTGCCCGCGGCCATATCTTTCATGATGGTAATAAACGCACTGCCTTTTTTGTTACC
ATGGCCTTTCTTAGGCGTAATGGCATCCGTATTCACGATACTGACAATACACTGGAAAATCTGACGGTCGAAGCAGCTAC
AGGGGAAAAAACAGTAGACCAGTTGGCACAGTATTTGCGAAAACAGGTGGATGATCCCCTTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT149969 WP_002886901.1 NZ_CP048778:c4775441-4775199 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT149969 NZ_CP064363:230805-231026 [Salmonella enterica subsp. arizonae]
ATGCAAACCTATACTTCTACCCAGGCCAGGGCCAACATTTCCACCGTGCTGGATACTGCGTTAAATGGCGAGCCTGTTGA
AATCACCCGTCGTGATGGCAGCGCCGCCGTGCTTATCAGCAAAGCCGAATTCGAAGCCTGGCAAAATGCCAAACTCGACG
CGGAATTTGATGCCATCATGCAACGTCATGAACACACTATCAGGGCACTGACTGACCGATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References