Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-RelB |
Location | 4774925..4775441 | Replicon | chromosome |
Accession | NZ_CP048778 | ||
Organism | Klebsiella pneumoniae strain EGKP7 |
Toxin (Protein)
Gene name | relE | Uniprot ID | J2XDK6 |
Locus tag | G4D19_RS23490 | Protein ID | WP_002886902.1 |
Coordinates | 4774925..4775209 (-) | Length | 95 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | R4Y888 |
Locus tag | G4D19_RS23495 | Protein ID | WP_002886901.1 |
Coordinates | 4775199..4775441 (-) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
G4D19_RS23465 (4770341) | 4770341..4770604 | - | 264 | WP_014908078.1 | PTS sugar transporter subunit IIB | - |
G4D19_RS23470 (4770734) | 4770734..4770907 | + | 174 | WP_032414892.1 | hypothetical protein | - |
G4D19_RS23475 (4770910) | 4770910..4771653 | + | 744 | WP_021441079.1 | MurR/RpiR family transcriptional regulator | - |
G4D19_RS23480 (4772010) | 4772010..4774148 | + | 2139 | WP_004186701.1 | anaerobic ribonucleoside-triphosphate reductase | - |
G4D19_RS23485 (4774457) | 4774457..4774921 | + | 465 | WP_023302390.1 | anaerobic ribonucleoside-triphosphate reductase-activating protein | - |
G4D19_RS23490 (4774925) | 4774925..4775209 | - | 285 | WP_002886902.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
G4D19_RS23495 (4775199) | 4775199..4775441 | - | 243 | WP_002886901.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
G4D19_RS23500 (4775519) | 4775519..4777429 | - | 1911 | WP_009486549.1 | PRD domain-containing protein | - |
G4D19_RS23505 (4777452) | 4777452..4778606 | - | 1155 | WP_023302389.1 | lactonase family protein | - |
G4D19_RS23510 (4778673) | 4778673..4779413 | - | 741 | WP_002886899.1 | KDGP aldolase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 11125.95 Da Isoelectric Point: 10.3787
>T149969 WP_002886902.1 NZ_CP048778:c4775209-4774925 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL
Download Length: 285 bp
>T149969 NZ_CP064363:231023-231406 [Salmonella enterica subsp. arizonae]
ATGATTTGGGTCAGCGCGCAGGAAGTCATTGCCTTCCACGATCGTATTTTGCAACGCTTTCCCGGAGTGGTTGGCCTGTC
TGACCCTGGCAGAGCACAGGCATTGATTTATCGGGTGCAGAATCGTGTTCACTACGAAGGCGTTACTGACCTGTTTGAAC
TGGCGGCTACCTACTGGGTCGCTATTGCCCGCGGCCATATCTTTCATGATGGTAATAAACGCACTGCCTTTTTTGTTACC
ATGGCCTTTCTTAGGCGTAATGGCATCCGTATTCACGATACTGACAATACACTGGAAAATCTGACGGTCGAAGCAGCTAC
AGGGGAAAAAACAGTAGACCAGTTGGCACAGTATTTGCGAAAACAGGTGGATGATCCCCTTTAA
ATGATTTGGGTCAGCGCGCAGGAAGTCATTGCCTTCCACGATCGTATTTTGCAACGCTTTCCCGGAGTGGTTGGCCTGTC
TGACCCTGGCAGAGCACAGGCATTGATTTATCGGGTGCAGAATCGTGTTCACTACGAAGGCGTTACTGACCTGTTTGAAC
TGGCGGCTACCTACTGGGTCGCTATTGCCCGCGGCCATATCTTTCATGATGGTAATAAACGCACTGCCTTTTTTGTTACC
ATGGCCTTTCTTAGGCGTAATGGCATCCGTATTCACGATACTGACAATACACTGGAAAATCTGACGGTCGAAGCAGCTAC
AGGGGAAAAAACAGTAGACCAGTTGGCACAGTATTTGCGAAAACAGGTGGATGATCCCCTTTAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9045.55 Da Isoelectric Point: 6.3340
>AT149969 WP_002886901.1 NZ_CP048778:c4775441-4775199 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL
Download Length: 243 bp
>AT149969 NZ_CP064363:230805-231026 [Salmonella enterica subsp. arizonae]
ATGCAAACCTATACTTCTACCCAGGCCAGGGCCAACATTTCCACCGTGCTGGATACTGCGTTAAATGGCGAGCCTGTTGA
AATCACCCGTCGTGATGGCAGCGCCGCCGTGCTTATCAGCAAAGCCGAATTCGAAGCCTGGCAAAATGCCAAACTCGACG
CGGAATTTGATGCCATCATGCAACGTCATGAACACACTATCAGGGCACTGACTGACCGATGA
ATGCAAACCTATACTTCTACCCAGGCCAGGGCCAACATTTCCACCGTGCTGGATACTGCGTTAAATGGCGAGCCTGTTGA
AATCACCCGTCGTGATGGCAGCGCCGCCGTGCTTATCAGCAAAGCCGAATTCGAAGCCTGGCAAAATGCCAAACTCGACG
CGGAATTTGATGCCATCATGCAACGTCATGAACACACTATCAGGGCACTGACTGACCGATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GMH2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GLP0 |