Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1066476..1067137 Replicon chromosome
Accession NZ_CP048751
Organism Brevundimonas mediterranea strain D151-2-6

Toxin (Protein)


Gene name vapC Uniprot ID B4W8E1
Locus tag GYM46_RS05280 Protein ID WP_008263481.1
Coordinates 1066700..1067137 (+) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G7EFJ5
Locus tag GYM46_RS05275 Protein ID WP_040349912.1
Coordinates 1066476..1066703 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GYM46_RS05255 1062151..1062978 - 828 WP_155988182.1 tol-pal system protein -
GYM46_RS05260 1063043..1064179 - 1137 WP_008262016.1 DUF3667 domain-containing protein -
GYM46_RS05265 1064289..1064843 - 555 WP_008259557.1 peptidoglycan-associated lipoprotein Pal -
GYM46_RS05270 1064960..1066333 - 1374 WP_008264114.1 Tol-Pal system protein TolB -
GYM46_RS05275 1066476..1066703 + 228 WP_040349912.1 hypothetical protein Antitoxin
GYM46_RS05280 1066700..1067137 + 438 WP_008263481.1 PIN domain-containing protein Toxin
GYM46_RS05285 1067141..1067971 - 831 WP_008262228.1 hypothetical protein -
GYM46_RS05290 1067976..1068428 - 453 WP_008260741.1 protein TolR -
GYM46_RS05295 1068432..1069184 - 753 WP_008259719.1 protein TolQ -
GYM46_RS05300 1069326..1069751 - 426 WP_008262994.1 hypothetical protein -
GYM46_RS05305 1069779..1070237 - 459 WP_008261752.1 tol-pal system-associated acyl-CoA thioesterase -
GYM46_RS05310 1070247..1070585 - 339 WP_198004316.1 hypothetical protein -
GYM46_RS05315 1070701..1071732 - 1032 WP_008260837.1 Holliday junction branch migration DNA helicase RuvB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-127)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15929.11 Da        Isoelectric Point: 5.1334

>T149951 WP_008263481.1 NZ_CP048751:1066700-1067137 [Brevundimonas mediterranea]
MTYLLDVNVLIALVDPRHVFHDTANGWFQREAAGSWATCPITENGLVRIVGNSRYRNPVGPPSEIVRILELLRDMAGHVF
WPDAISLADDRLFDPSALTTPEQITDAYLLALAVSNGGRLATLDRRLSPDAVRDGRAALHLVTDA

Download         Length: 438 bp

>T149951 NZ_CP064352:c3728585-3727668 [Klebsiella pneumoniae subsp. pneumoniae ATCC 43816]
ATGGATATACAGGCGCCCTATTATCGGCAGGTTGCTCTGTTAATGCAGGTTTTACCCTATGTTGCCGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACGGCAATCAATCTCTTTATCCGTGATTTCCCACGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCGATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAACGCTGTATTACAAGCTAATCGTTCCGATGAGATGCGTGTCGTTGTTACTACCGATAGCGCACAAATAAA
GATAGAGGTCTCACCGGTCGCACGGGGAACATTATATCCACCACAGGAGCGAGAGGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTTAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACTTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8347.52 Da        Isoelectric Point: 4.7527

>AT149951 WP_040349912.1 NZ_CP048751:1066476-1066703 [Brevundimonas mediterranea]
MRTTLAIDDDVLNAARAIAVHQDRTIGEVVSELAREALQKRETTVRFRNGVPLLPDRPGPMVTLEDVNALRDELP

Download         Length: 228 bp

>AT149951 NZ_CP064352:c3729349-3728591 [Klebsiella pneumoniae subsp. pneumoniae ATCC 43816]
ATGCCATCAAAATTAAACTGGCTGCTGCAAAACAGTGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCGGCATGC
CATCTCGCCCTCTCTGGCCTTTAAATACACGCAAAGTGGCTGGTTAAAAAAACGAGGTAACGGCGTATACGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAACCAGCTAGCCGCTCCGGTGTATGTCGCTGGGCTCAGT
AGCTTAGTCTGGCAGGGTCGTTCACACTATCTACAGCTCAAACAAAACCAGTGCTGGCTGAGTATGGAAAATAAAGCGCT
GCTGCCAAAATGGTTCAGGGAATTCCCGGGTGTAGAGTGGATAGTCATATCGGGCCAAAAACTACCGGTGCTGGATGATA
AATACCGCGTACTGCTTGATGTAAAAGGGAAAAGACTCACCGGCAGTGCGCCGGAACTGGCTGCTTACGAGTTGTTGAGC
GCGGTACCGGGGACCCTCTCATTTAACCACGCGGCAGAGCTTTTCCAGGGACTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTGCTTTCTGTCAGCCAGTCCGTGCAGACCAAGCGTTTGTATCTCTTTTTCGCCAGTTTTTACGAGCATGGTTGGC
TCAGACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGTAAGCGGCAAATCGTGGTAAATGGCAAGTTCAATGCTCAA
TACCAAATCACTGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4W8E1

Antitoxin

Source ID Structure
AlphaFold DB A0A6G7EFJ5

References